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首页> 外文期刊>Materials science & engineering >Aligned multi-walled carbon nanotubes with nanohydroxyapatite in a 3D printed polycaprolactone scaffold stimulates osteogenic differentiation
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Aligned multi-walled carbon nanotubes with nanohydroxyapatite in a 3D printed polycaprolactone scaffold stimulates osteogenic differentiation

机译：用纳米羟基磷灰石对准的多壁碳纳米管在3D印刷的聚己内酯支架中刺激成骨分化

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摘要

The development of highly biomimetic scaffolds in terms of composition and structures, to repair or replace damaged bone tissues, is particularly relevant for tissue engineering. This paper investigates a 3D printed porous scaffold containing aligned multi-walled carbon nanotubes (MWCNTs) and nano-hydroxyapatite (nHA), mimicking the natural bone tissue from the nanoscale to macroscale level. MWCNTs with similar dimensions as collagen fibres are coupled with nHA and mixed within a polycaprolactone (PCL) matrix to produce scaffolds using a screw-assisted extrusion-based additive manufacturing system. Scaffolds with different material compositions were extensively characterised from morphological, mechanical and biological points of views. Transmission electron microscopy and polarised Raman spectroscopy confirm the presence of aligned MWCNTs within the printed filaments. The PCL/HA/MWCNTs scaffold are similar to the nanostructure of native bone and shows overall increased mechanical properties, cell proliferation, osteogenic differentiation and scaffold mineralisation, indicating a promising approach for bone tissue regeneration.
机译：在组合物和结构方面，高度仿生支架的开发，修复或替换受损骨组织，特别适用于组织工程。本文研究了含有对齐的多壁碳纳米管（MWCNT）和纳米羟基磷灰石（NHA）的3D印刷多孔支架，将天然骨组织从纳米载体中模仿到Macroscale水平。具有与胶原纤维相似尺寸的MWCNT与NHA偶联并在聚己内酯（PCL）基质内混合以使用螺杆辅助挤出基添加制造系统生产支架。具有不同材料组合物的支架广泛地表征了形态学，机械和生物学观点。透射电子显微镜和偏振拉曼光谱证实印刷长丝内的对齐MWNTS存在。 PCL / HA / MWCNTS支架类似于天然骨的纳米结构，并显示出总体增加的机械性能，细胞增殖，成骨分化和支架矿化，表明骨组织再生的有希望的方法。

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