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首页> 外文期刊>Materials science & engineering >Facile synthesis, microstructure, formation mechanism, in vitro biocompatibility, and drug delivery property of novel dendritic TiO_2 nanofibers with ultrahigh surface area
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Facile synthesis, microstructure, formation mechanism, in vitro biocompatibility, and drug delivery property of novel dendritic TiO_2 nanofibers with ultrahigh surface area

机译：具有超高压表面积的体外合成，微观结构，形成机制，体外生物相容性和新型树突TiO_2纳米纤维的药物递送性能

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摘要

In this study, novel dendritic TiO2 nanofibers (D-Ti NFs) with ultrahigh surface area were for the first time synthesized through in situ hydrothermal treatment of the electrospun TiO2 nanofibers (E-Ti NFs) and their microstructure, formation mechanism, in vitro biocompatibility and drug delivery property were investigated. SEM observations showed that D-Ti NFs had dendritic and fibrous morphology with the controllable diameter of 899 +/- 26 nm to 1955 +/- 64 nm. TEM observations showed the individual D-Ti NF was assembled by numerous primary nanowires with the diameter of 7 +/- 1 nm. XRD pattern showed that the D-Ti NFs displayed the characteristic peaks at 24.1 degrees, 28.1 degrees, and 48.3 degrees, all of which were assigned to hydrogen titanium oxide hydrate. BET measurement indicated that D-Ti NFs had the ultrahigh specific surface area of 213.41 m(2)/g. D-Ti NFs showed good in vitro biocompatibility when exposed to Hela cells. After soaked in solution of tetracycline hydrochloride (TH, one of the representative antibiotics, model drug), D-Ti NFs supported the loading of TH with the loading efficiency of 63.73 +/- 4.61%. TH-loaded D-Ti NFs supported a sustained release model for TH when immersed in the phosphate buffer saline. After separately incubated with two representative types of bacteria: Escherichia coli and Staphylococcus aureus, TH-loaded D-Ti NFs showed excellent antibacterial property to inhibit the growth of the bacteria, indicating that the released TH was biologically active.
机译：在该研究中，具有超高表面积的新型树突TiO2纳米纤维（D-Ti NFS）是通过原位水热处理合成的电纺TiO2纳米纤维（E-Ti NFS）和微结构，形成机制，体外生物相容性的第一次合成研究了药物递送性质。 SEM观察结果表明，D-TI NFS具有树枝状和纤维形态，可控直径为899 +/- 26nm至1955 +/- 64nm。 TEM观察显示各自的D-Ti NF由无数初始纳米线组装，直径为7 +/-1nm。 XRD图案显示D-Ti NFS在24.1度，28.1度和48.3度下显示特征峰，所有这些都被分配给氧化钛水合物。 BET测量表明，D-TI NFS具有213.41m（2）/ g的超高比表面积。 D-Ti NFS在暴露于HeLa细胞时显示出良好的体外生物相容性。在浸泡盐酸四环素溶液（TH的溶液（Th之一代表抗生素，模型药物）后，D-Ti NFS支持载荷效率为63.73 +/- 4.61％。当浸入磷酸盐缓冲盐水中时，Thouded D-Ti NFS支持持续的释放模型。单独孵育后用两种代表性的细菌孵育：大肠杆菌和金黄色葡萄球菌，Th负载的D-Ti NFS显示出优异的抗菌性，以抑制细菌的生长，表明释放的TH在生物学上活跃。

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  • 来源
    《Materials science & engineering》 |2020年第10期|111100.1-111100.10|共10页
  • 作者

    Chen Song; Shen Lulu; Huang Di; Du Juan; Fan Xiaoxu; Wei Aili; Jia Lan; Chen Weiyi;

  • 作者单位

    Taiyuan Univ Technol Coll Biomed Engn Taiyuan 030024 Peoples R China;

    Taiyuan Univ Technol Coll Mat Sci & Engn Taiyuan 030024 Peoples R China;

    Taiyuan Univ Technol Coll Biomed Engn Taiyuan 030024 Peoples R China;

    Taiyuan Univ Technol Coll Mat Sci & Engn Taiyuan 030024 Peoples R China;

    Taiyuan Univ Technol Coll Mat Sci & Engn Taiyuan 030024 Peoples R China;

    Taiyuan Univ Technol Coll Mat Sci & Engn Taiyuan 030024 Peoples R China;

    Taiyuan Univ Technol Coll Mat Sci & Engn Taiyuan 030024 Peoples R China;

    Taiyuan Univ Technol Coll Biomed Engn Taiyuan 030024 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Dendritic TiO2 nanofibers; One-step hydrothermal synthesis; Biocompatibility; Drug delivery;

    机译：树突式TiO2纳米纤维;一步水热合成;生物相容性;药物递送;

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