...
首页> 外文期刊>Materials science & engineering >Ethyl ferulate/β-cyclodextrin inclusion complex inhibits edema formation
【24h】

Ethyl ferulate/β-cyclodextrin inclusion complex inhibits edema formation

机译:乙基丙烯/β-环糊精包合物抑制水肿形成

获取原文
获取原文并翻译 | 示例
           

摘要

Ethyl ferulate, a phenylpropanoid derived from rice hulls has aroused interest because of its antioxidant, anti-inflammatory and neuroprotective properties. However, it has low solubility in water which compromises the absorption in the gastrointestinal tract, decreases the bioavailability and compromises the reproducibility of the effects in vivo. To increase the solubility of ethyl ferulate, inclusion complexes were obtained by physical mixing, malaxing, lyophilization and spray drying and characterized using thermal analysis, XRD and FTIR. The complexes obtained were evaluated for ethyl ferulate content, stability, dissolution profile and evaluation of anti-inflammatory activity in vivo through carrageenan-induced paw edema model in rats. The inclusion complexes obtained resulted in increased solubility and stability compared to the isolated ethyl ferulate. In addition, the complexes obtained by malaxage, lyophilization and spray drying showed greater inhibition of the edema formation induced by carrageenan compared to ethyl ferulate 100 mg/kg v.o. The inclusion of ethyl ferulate in B-cyclodextrin resulted in the formation of stable inclusion complexes with potent antidematogenic activity possibly attributed to the increased solubility, dissolution profile of the active.
机译:乙基丙烯,衍生自水稻壳体的苯丙基丙醇,因为其抗氧化剂,抗炎和神经保护性能引起了兴趣。然而,它在水中具有低溶解度,这损害了胃肠道中的吸收,降低了生物利用度并损害了体内效果的再现性。为了增加乙基丙酮的溶解度,通过物理混合,爆轰,冻干和喷雾干燥获得包合物,并用热分析,XRD和FTIR表征。评估所得络合物的乙基含量,稳定性,溶解曲线和通过大鼠诱导的大鼠诱导的爪鞘模型进行抗炎活性的评价。与分离的乙基筛选相比,获得的包含配合物增加了溶解度和稳定性。此外,通过畸形,冻干和喷雾干燥获得的络合物表明,与乙基/ kg v.O.乙基/ kg v.o.在B-环糊精中包含乙基丙烯,导致形成稳定的含有稳定性的溶解性活性,可能归因于活性的溶解度增加,溶解曲线的增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号