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首页> 外文期刊>Materials science & engineering >Fabrication of novel dual thermo- and pH-sensitive poly (N-isopropylacrylamide-N-methylolacrylamide-acrylic acid) electrospun ultrafine fibres for controlled drug release
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Fabrication of novel dual thermo- and pH-sensitive poly (N-isopropylacrylamide-N-methylolacrylamide-acrylic acid) electrospun ultrafine fibres for controlled drug release

机译：新型双热能和pH敏感聚（N-异丙基丙烯酰胺-N-羟甲基丙烯酰胺 - 丙烯酸）电纺出用于受控药物释放的制备

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摘要

Dual temperature- and pH-sensitive materials used as drug carriers have attracted a particularly high level of interest. However, it is limited by low sensitivity to changes in conditions because of large size and low specific surface area. In this work, novel dual temperature- and pH-sensitive poly(N-isopropylacrylamide-N-methylolacrylamide acrylic acid) (PNIPAm-NMA-AAc) ultrafine fibres were successfully prepared by radical copolymerisation, electrospinning and thermal chemical treatment. The PNIPAm-NMA-AAc ultrafine fibres were characterized by Fourier transform infrared (FTIR), proton nuclear magnetic resonance (H-1 NMR), spectroscopy UV-visible spectroscopy, scanning electron microscopy (SEM) and cell counting kit-8 (CCK-8) assay. The uniformity and small size of PNIPAm-NMA-AAc ultrafine fibres with LCST range from 31 degrees C to 43 degrees C were used to drug carrier because of good thermal stability, no cytotoxic. Curcumin as a model drug was well distributed in PNIPAm-NMA-AAc ultrafine fibres. In addition, analysis of curcumin release at different pH values and temperatures confirmed that the PNIPAm-NMA-AAc ultrafine fibres are responsive to both temperature and pH. The maximum amount of curcumin released was 98.47% +/- 1.87%. In addition, the release mechanism of curcumin-based PNIPAm-NMA-AAc ultrafine fibres was shown to conform to Fickian diffusion (r(2) = 0.95). These results indicated that dual-responsive PNIPAm-NMA-AAc ultrafine fibres are promising as drug carriers.
机译：用作药物载体的双温度和pH敏感材料吸引了特别高的兴趣。然而，由于大尺寸和低比表面积，它受到条件变化的敏感性的限制。在这项工作中，通过自由基共聚，静电纺丝和热化学处理成功制备了新型双重温度和pH敏感的聚（N-异丙基丙烯酰胺-N-羟甲基丙烯酰胺丙烯酸）超细纤维。通过傅立叶变换红外（FTIR），质子核磁共振（H-1 NMR），光谱紫外纹光谱，扫描电子显微镜（SEM）和细胞计数套件-8（CCK- 8）测定。由于良好的热稳定性，使用具有LCST范围为31℃至43摄氏度的PNIPAM-NMA-AAC超细纤维的均匀性和小尺寸。由于良好的热稳定性，没有细胞毒性。姜黄素作为模型药物在泊普 - NMA-AAC超细纤维中分布很好。此外，在不同pH值和温度下的姜黄素释放的分析证实，肺蛋白-NMA-AAC超细纤维对温度和pH响应。释放的最大姜黄素量为98.47％+/- 1.87％。此外，证明了姜黄素基泊米-NMA-AAC超细纤维的释放机制符合Fickian扩散（R（2）> = 0.95）。这些结果表明，双响应性泊米-NMA-AAC超细纤维是有前途的药物载体。

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  • 来源
    《Materials science & engineering》 |2020年第10期|111050.1-111050.12|共12页
  • 作者

    Wei Zhimei; Lin Qingyu; Yang Jie; Long Shengru; Zhang Gang; Wang Xiaojun;

  • 作者单位

    Sichuan Univ Inst Mat Sci & Technol Chengdu 610065 Peoples R China;

    Sichuan Univ Coll Life Sci Res Ctr Analyt Instrumentat Key Lab Bioresource & Ecoenvironm Minist Educ 29 Wangjiang Rd Chengdu 610064 Peoples R China;

    Sichuan Univ Inst Mat Sci & Technol Chengdu 610065 Peoples R China|Sichuan Univ State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China;

    Sichuan Univ Inst Mat Sci & Technol Chengdu 610065 Peoples R China;

    Sichuan Univ Inst Mat Sci & Technol Chengdu 610065 Peoples R China;

    Sichuan Univ Inst Mat Sci & Technol Chengdu 610065 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Dual sensitive; Electrospinning; Ultrafine fibres; Drug carriers;

    机译：双敏感;静电纺丝;超细纤维;药物载体;

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