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首页> 外文期刊>Materials science & engineering >Functional behavior of chitosan/gelatin/silica-gentamicin coatings by electrophoretic deposition on surgical grade stainless steel
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Functional behavior of chitosan/gelatin/silica-gentamicin coatings by electrophoretic deposition on surgical grade stainless steel

机译：外科级不锈钢电泳沉积壳聚糖/明胶/二氧化硅蛋白涂层的功能性能

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摘要

Metals are used in several orthopedic applications as fixation elements for the stabilization of fractures or as prostheses. One of the most common orthopedic biomaterials in many developing countries is surgical grade stainless steel (SS). However, its use as permanent implant in orthopedic surgery is conditioned due to its limited corrosion resistance in physiological media, lack of osseointegration, and absence of antibacterial effect. The aim of this work is to generate a degradable coating with antibacterial properties for stainless steel to be used in implants/medical devices. The coating is composed of a biopolymer/silica-gentamicin nanoparticles composite obtained by electrophoretic deposition (EPD) on surgical grade stainless steel plates. The coating surface was characterized by microscopic examination, and in vitro performance was evaluated after immersion in phosphate-buffered saline (PBS) solution, simulated body fluid (SBF), and cell culture medium, to analyze coating degradation, antibiotics release, cell attachment (ST-2 stromal cells), and antibacterial (Escherichia coli and Staphylococcus aureus) properties. EPD coatings were uniform and covered homogeneously the surface of the SS substrate. Also the distribution of silica-gentamicin nanoparticles was homogeneous on the coated area. The degradation of the chitosan-gelatin coatings was evident after 7 days of immersion. The gentamicin release led to excellent antibacterial behavior at 24 h, meanwhile the cell proliferation (at 7 days culture) was not inhibited. The results show that the coating system exhibits promising behavior which could contribute to prevent hospital infections at early implantation times.
机译：金属用于若干整形外科应用中，作为抗骨折或假体稳定的固定元素。许多发展中国家最常见的骨科生物材料之一是外科手术级不锈钢（SS）。然而，在整形外科手术中作为永久植入物的用途是由于其在生理介质中的耐腐蚀性有限，缺乏骨整合并且没有抗菌作用而受到调节。这项工作的目的是产生可降解的涂层，其具有用于植入物/医疗装置的不锈钢的抗菌性能。涂层由通过电泳沉积（EPD）在外科级不锈钢板上获得的生物聚合物/二氧化硅蛋白纳米粒子组成。涂层表面的特征在于微观检查，并在浸泡磷酸盐缓冲盐水（PBS）溶液中，模拟体液（SBF）和细胞培养基中评价体外性能，分析涂层降解，抗生素释放，细胞附着（ ST-2基质细胞），和抗菌（大肠杆菌和金黄色葡萄球菌）性质。 EPD涂层均匀，均匀地覆盖SS衬底的表面。还在涂覆区域上均匀的二氧化硅 - 庆大霉素纳米颗粒的分布。在浸渍7天后，壳聚糖 - 明胶涂层的降解是明显的。庆大霉素释放导致24小时的优异抗菌性能，同时细胞增殖（7天培养）不受抑制。结果表明，涂​​料系统表现出有助于的行为，这可能有助于预防早期植入时间的医院感染。

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