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首页> 外文期刊>Materials science & engineering >Laser-induced topographies enable the spatial patterning of co-cultured peripheral nervous system cells
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Laser-induced topographies enable the spatial patterning of co-cultured peripheral nervous system cells

机译：激光诱导的地形使共同培养的外周神经系统细胞的空间图案化

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摘要

The peripheral nervous system comprises glia and neurons that receive the necessary cues for their adhesion and proliferation from their extracellular milieu. In this study, a spatial platform of pseudoperiodic morphologies including patterns of nano- and micro- structures on Si were developed via direct ultrafast-laser structuring and were used as substrates for the patterning of co-cultured neuronal cells. The response of murine Schwann (SW10) and Neuro2a (N2a) cells were investigated both in monocultures and in a glia and neuronal co-culture system. Our results denoted that different types of neural tissue cells respond differently to the underlying topography, but furthermore, the presence of the glial cells alters the adhesion behavior of the neuronal cells in their co-culture. Therefore, we envisage that direct laser structuring that enables spatial patterning of the cells of the nervous system in a controllable manner according to the research needs, could in the future be a useful tool for understanding neural network interfaces and their electrical activity, synaptic processes and myelin formation.
机译：外周神经系统包括胶质增长和神经元，该胶质胶质和神经元从其细胞外环境中获得必要的粘附和增殖。在该研究中，通过直接超快激光结构改造包括Si的纳米和微结构模式的假偶体形态的空间平台，并用作共培养神经元细胞的图案化的基材。在单苗圃和胶林胶质细胞和神经元共培养系统中研究了鼠施万（SW10）和Neuro2a（N2A）细胞的响应。我们的结果表示，不同类型的神经组织细胞对潜在的地形反应不同，但此外，胶质细胞的存在改变了神经元细胞在其共培养中的粘附性能。因此，我们设想直接激光结构，使得能够根据研究需求以可控的方式进行空间图案化神经系统的细胞的空间图案化，以便将来可以是理解神经网络接口及其电活动，突触过程和突触过程的有用工具髓鞘形成。

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  • 来源
    《Materials science & engineering》 |2020年第10期|111144.1-111144.12|共12页
  • 作者

    Angelaki D.; Kavatzikidou P.; Fotakis C.; Stratakis E.; Ranella A.;

  • 作者单位

    Fdn Res & Technol Hellas IESL FORTH Inst Elect Struct & Laser Iraklion 71110 Greece|Univ Crete Dept Phys Iraklion 71003 Greece;

    Fdn Res & Technol Hellas IESL FORTH Inst Elect Struct & Laser Iraklion 71110 Greece;

    Fdn Res & Technol Hellas IESL FORTH Inst Elect Struct & Laser Iraklion 71110 Greece|Univ Crete Dept Phys Iraklion 71003 Greece;

    Fdn Res & Technol Hellas IESL FORTH Inst Elect Struct & Laser Iraklion 71110 Greece|Univ Crete Dept Phys Iraklion 71003 Greece;

    Fdn Res & Technol Hellas IESL FORTH Inst Elect Struct & Laser Iraklion 71110 Greece;

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  • 正文语种 eng
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  • 关键词

    Glia-neurons co-culture; Neuronal cell pattern; Laser structuring; Tissue engineering;

    机译：Glia-neurons共培养;神经元细胞模式;激光结构化;组织工程;

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