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首页> 外文期刊>Materials science & engineering >Biocompatible indocyanine green loaded PLA nanofibers for in situ antimicrobial photodynamic therapy
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Biocompatible indocyanine green loaded PLA nanofibers for in situ antimicrobial photodynamic therapy

机译：生物相容性吲哚菁绿载PLA纳米纤维，用于原位抗菌光动力学治疗

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Chronic wounds and their associated bacterial infections are major issues in modern health care systems. Therefore, antimicrobial resistance (AMR), treatment costs, and number of disability-adjusted life-years have gained more interest. Recently, photodynamic therapy emerged as an effective approach against resistant and naive bacterial strains with a low probability of creating AMR. In this study, needleless electrospinning was used to produce an indocyanine green (ICG) loaded poly(D,L-lactide) nanofibrous mesh as a photoresponsive wound dressing. The non-woven mesh had a homogeneous nanofibrous structure and showed long-term hydrolytic stability at different pH values. The antimicrobial activity was tested against several bacterial strains, namely Staphylococcus saprophyticus subsp. bovis, Escherichia coil DH5 alpha, and Staphylococcus aureus subsp. aureus. Upon irradiation with a laser of a specific wavelength (lambda = 810 nm), the bacterial viability was significantly reduced by 99.978% (3.66 log(10)), 99.699% (2.52 log(10)), and 99.977% (3.64 log(10)), respectively. The nanofibrous mesh showed good biocompatibility, which was confirmed by the proliferation of mouse fibroblasts (L929) on the surface and into deeper parts of the mesh. Furthermore, a favorable proangiogenic effect was observed in ovo using the chorioallantoic membrane assay. In general, it can be concluded that ICG loaded nanofibers as an innovative wound dressing represent a promising strategy against chronic wounds associated with skin infections.
机译：慢性伤口及其相关的细菌感染是现代医疗保健系统的主要问题。因此，抗菌性抗性（AMR），治疗成本和残疾调整后的寿命年的数量越来越感兴趣。最近，光动力疗法被出现为抗抗性和幼稚细菌菌株的有效方法，其产生AMR的概率低。在这项研究中，用于生产吲哚菁绿（ICG）的吲哚菁（ICG）的聚（D，L-丙交酯）纳米纤维网作为光致伤口敷料。非织造网格具有均相纳米纤维结构，并在不同的pH值下显示长期水解稳定性。针对几种细菌菌株测试抗微生物活性，即葡萄球菌患者。 Bovis，大肠杆菌卷DH5α，和金黄色葡萄球菌亚空白。金黄色葡萄球菌。在用特定波长（Lambda = 810nm）的激光照射时，细菌活力明显减少99.978％（3.66对数（10）），99.699％（2.52 log（10）），99.977％（3.64伐木10））分别。纳米纤维网显示良好的生物相容性，其通过在表面上的小鼠成纤维细胞（L929）的增殖并进入网状物的深层部分来证实。此外，使用细胞增性膜测定法在OVO中观察到有利的致剂效果。一般来说，可以得出结论，ICG负载纳米纤维作为一种创新的伤口敷料，代表了针对与皮肤感染相关的慢性伤口的有希望的策略。

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