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首页> 外文期刊>Materials science & engineering >Long-acting mucoadhesive thermogels for improving topical treatments of dry eye disease
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Long-acting mucoadhesive thermogels for improving topical treatments of dry eye disease

机译：长效粘膜粘附热凝胶，用于改善干眼病的局部处理

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摘要

Dry eye disease (DED) is the most common ocular disorder that causes persistent discomfort and blurry vision in patients. Despite pharmacotherapy strategies, the current topical administration of eye drops remains a great challenge owing to their low bioavailability and short residence time. Herein, we demonstrate an effective topical treatment of DED via rational design of a long-acting and mucoadhesive drug delivery system. Specifically, the drug carrier is a chemically ternary material system consisting of gelatin that serves as an enzyme-mediated degradable matrix, poly(N-isopropylacrylamide) as a thermo-responsive regulator, and lectin Helix pomatia agglutinin as a mucus-binding component. The long-acting drug release performance is exploited via initiator effects during the synthesis of the thermo-responsive polymer, while the mucoadhesive feature is inherited from the mucus-binding material. In a rabbit model of DED, a pharmacotherapy based on one-time topical administration of epigallocatechin gallate-loaded carrier onto the cul-de-sac could effectively repair the defective corneal epithelium via mitigating cellular inflammation, oxidative stress, and cell apoptosis for a sustained period over 14 days. These findings on the initiator and synergy effects in the development of the advanced ophthalmic formulation show great promise for efficient management of complex ocular diseases by a simple topical administration route.
机译：干眼症（DED）是最常见的眼部病症，导致患者持续不适和模糊的视觉。尽管药拍疗法策略，但由于其低生物利用度和短暂停留时间，目前的局部局部局部局部滴滴仍然是一个巨大的挑战。在此，我们展示了一种有效的局部通过合理设计的长效和粘膜粘附药物输送系统。具体地，药物载体是由明胶组成的化学三元材料系统，其用作酶介导的可降解基质，聚（N-异丙基丙烯酰胺）作为热响应性调节剂，以及凝集素螺旋POMATIA凝集素作为粘液结合组分。通过在热响应聚合物的合成期间通过引发剂效应利用长效药物释放性能，而粘液粘附特征是从粘液结合材料遗传的。在兔子模型中，基于一次性局部局部局部局部局部局部储存的载体上的药物疗法在CUL-DE-SAC上可以通过减轻细胞炎症，氧化应激和细胞凋亡来有效地修复缺陷的角膜上皮。持续的超过14天。这些调查结果对先进眼科制剂的发育者和协同效应的调查结果表明，通过简单的局部给药路线对复杂眼部疾病的有效管理有效。

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