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首页> 外文期刊>Materials science & engineering >Magnetic resonance activatable thermosensitive liposomes for controlled doxorubicin delivery
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Magnetic resonance activatable thermosensitive liposomes for controlled doxorubicin delivery

机译：用于受控的多码本素递送的磁共振活化热敏脂质体

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摘要

To limit the massive cytotoxicity of chemotherapeutic agents, it is desirable to establish an appropriate subtle blend of formulation design based on a dual-responsive strategy. In this study, a combined therapeutic platform based on magnetic thermosensitive liposomes (Lip(TS-GD)) was developed. The incorporation of chelated-gadolinium imparted magnetic properties to thermosensitive liposomes (Lip(TS)). The application of an ultra high field magnetic resonance imaging (UHF-MRI) induced hyperthermia, thus provided an improved chemotherapeutic effect of Doxorubicin (DOX). The paramagnetic platform demonstrated thermal sensitivity over a narrow temperature range starting at 37.8 degrees C, hence the release of DOX from Lip(TS-GD) can be well triggered by inducing hyperthermia using UHF-MRI application. The prepared Lip(TS-GD) were below 200 nm in diameter and an adequate release of DOX reaching 68% was obtained after 1 h UHF-MRI exposure. Profoundly, triple-negative breast cancer (TNBC) cells that were treated with Lip(TS-GD) and subjected thereafter to UHF-MRI exposure for 60 min showed 36% viability. Hemocompatibility studies of Lip(TS-GD) showed a physiological coagulation time and minimal hemolytic potential. Conclusively, Lip(TS-GD) guided local delivery of DOX to solid tumors will potentially raise the therapeutic index, thus reducing the required dose and frequency of DOX administered systemically without influencing the adjacent tissues.
机译：为了限制化学治疗剂的巨大细胞毒性，期望基于双响应策略建立适当的整理设计。在该研究中，开发了基于磁热敏脂质体（唇（TS-GD））的组合治疗平台。将螯合 - 钆赋予磁性掺入热敏脂质体（唇（TS））。超高场磁共振成像（UHF-MRI）诱导的热疗的应用提供了改善的多柔比星（DOX）的化学治疗效果。顺磁平台在37.8摄氏度开始的窄温度范围内显示出热敏率，因此可以通过使用UHF-MRI应用来诱导高温释放唇缘（TS-GD）的DOX释放。在1小时UHF-MRI暴露后，将制备的唇缘（TS-Gd）低于200nm的直径，并且在达到68％的情况下达到68％的足够释放。深受唇（TS-Gd）处理的三阴性乳腺癌（TNBC）细胞，此后对UHF-MRI暴露进行60分钟显示36％的活力。唇缘（TS-Gd）的血液相位性研究显示了生理凝固时间和最小的溶血潜力。结论，唇缘（TS-GD）将DOX局部递送到实体肿瘤将可能提高治疗指数，从而降低了系统性上施用的DOX所需剂量和频率，而不会影响相邻组织。

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