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Enhanced antimicrobial and antifungal property of two-dimensional fibrous material assembled by N-halamine polymeric electrolytes

机译:由N-卤素聚合物电解质组装的二维纤维材料的增强抗微生物和抗真菌性能

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摘要

Microbial contamination and biofilm formation cause serious issues in medical, household, industrial and environmental applications. In this study, a series of cationic and anionic N-halamine polymeric precursors, poly (N,N-dimethyl-N-decyl ammonium ethyl methacrylate-co-methacrylamide) (PQDM) and poly (acrylic acid-co-methacrylamide) (PAM), were synthesized and coated onto cotton fabrics through the layer-by-layer (LBL) assembly technique. The coated LBL cotton swatches were characterized by Scanning Electron Microscopy, Fourier transform infrared spectroscopy, and contact angle evaluation. The stability of the LBL samples towards artificial sweat and home laundering was evaluated. The LBL treated fabrics demonstrated effective antimicrobial efficacy and biofilm-controlling against Gram-positive bacteria, Gram-negative bacteria, and Fungi. In vitro cytocompatibility test towards mouse fibroblast cell indicated that the LBL coated cotton fabrics are cytocompatible, pointing to great potentialities of the LBL assembled fabrics for future biomedical applications.
机译:微生物污染和生物膜形成导致医疗,家庭,工业和环境应用中的严重问题。在该研究中,一系列阳离子和阴离子N-卤素聚合物前体,聚(N,N-二甲基-N-乙基甲基丙烯酸氢铵 - 甲基丙烯酰胺)(PQDM)和聚(丙烯酸 - 共甲基丙烯酰胺)(PAM ),通过层逐层(LBL)组装技术合成并涂覆在棉织物上。通过扫描电子显微镜,傅里叶变换红外光谱和接触角评估,表征涂覆的LBL棉花样片。评估了LBL样品对人造汗和洗涤洗涤的稳定性。 LBL处理的织物证明了针对革兰氏阳性细菌,革兰氏阴性细菌和真菌的有效抗微生物疗效和生物膜控制。对小鼠成纤维细胞的体外细胞相容性试验表明,LBL涂覆的棉织物是细胞系相态,指向LBL组装织物的巨大潜力,用于未来的生物医学应用。

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