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首页> 外文期刊>Materials science & engineering >Effect of ultrasonic micro-arc oxidation on the antibacterial properties and cell biocompatibility of Ti-Cu alloy for biomedical application
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Effect of ultrasonic micro-arc oxidation on the antibacterial properties and cell biocompatibility of Ti-Cu alloy for biomedical application

机译：超声波微弧氧化对生物医学应用Ti-Cu合金抗菌性能和细胞生物相容性的影响

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摘要

In order to improve antibacterial properties and cell biocompatibility of Ti-Cu alloy, an ultrasonic micro-arc oxidation (UMAO) has been applied to Ti-Cu alloy. The corrosion resistance, antibacterial activity and cell compatibility of Ti-Cu alloy before and after UMAO were studied in detail by means of electrochemical test, plate count method and CCK-8 test scanning electron microscopy (SEM) technology to evaluate the application possibilities of UMAO as a surface bio-modification method for Ti-Cu alloy. The surface microstructure characterisation showed that a typical porous coating with a pore diameter of 3-8 mu m and a thickness of 5-15 mu m was formed on the surface of the Ti-Cu alloy, which significantly improved the surface roughness and hydrophilicity. The plate count method demonstrated that UMAO coatings on Ti-Cu alloy showed strong antibacterial activity (= 99%) against Staphylococcus aureus (S. aureus) even after being immersed in a physiological saline for up to 20 days, indicating that UMAO-treated Ti-Cu alloy had very strong long-term antibacterial properties. It is believed that the strong long-term antimicrobial properties of Ti-Cu-UMAO samples were mainly due to the formation of Cu2O and CuO in UMAO coatings. The results of cell compatibility evaluation showed that UMAO treatment did not bring about cytotoxicity but improved the early adhesion of MC3T3 cell.
机译：为了改善Ti-Cu合金的抗菌性和细胞生物相容性，已经将超声波微弧氧化（UMAO）应用于Ti-Cu合金。通过电化学测试，板数法和CCK-8测试扫描电子显微镜（SEM）技术详细研究了UMAO之前和之后的Ti-Cu合金的耐腐蚀性，抗菌活性和细胞相容性，以评估UMAO的应用可能性作为Ti-Cu合金的表面生物改性方法。表面微观结构表征显示，在Ti-Cu合金的表面上形成孔径为3-8μmm和厚度为5-15μm的典型多孔涂层，从而显着提高了表面粗糙度和亲水性。平板计数方法表明，即使在浸入生理盐水中长达20天后，Ti-Cu合金上的UMAO涂层表明抗菌活性强（> = 99％）抵抗金黄色葡萄球菌（S. aureus），表明UMAO治疗Ti-Cu合金具有非常强烈的长期抗菌性能。据信，Ti-Cu-UMAO样品的强长期抗微生物性质主要是由于UMAO涂层中Cu2O和CuO的形成。细胞相容性评价的结果表明，UMAO治疗没有带来细胞毒性，但改善了MC3T3细胞的早期粘附性。

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  • 来源
    《Materials science & engineering》 |2020年第10期|110921.1-110921.15|共15页
  • 作者

    Hu Jiali; Li Haixia; Wang Xiaoyan; Yang Lei; Chen Mian; Wang Renxian; Qin Gaowu; Chen Da-Fu; Zhang Erlin;

  • 作者单位

    Northeastern Univ Sch Mat Sci & Engn Key Lab Anisotropy & Texture Mat Educ Minist China Shenyang 110819 Peoples R China;

    Northeastern Univ Sch Mat Sci & Engn Key Lab Anisotropy & Texture Mat Educ Minist China Shenyang 110819 Peoples R China;

    Northeastern Univ Sch Met Shenyang 110819 Peoples R China;

    Northeastern Univ Sch Mat Sci & Engn Key Lab Anisotropy & Texture Mat Educ Minist China Shenyang 110819 Peoples R China|Northeastern Univ Res Ctr Met Wires Shenyang 110819 Peoples R China;

    Northeastern Univ Sch Mat Sci & Engn Key Lab Anisotropy & Texture Mat Educ Minist China Shenyang 110819 Peoples R China;

    Beijing Jishuitan Hosp Beijing Res Inst Orthopaed & Traumatol Lab Bone Tissue Engn Beijing Lab Biomed Mat Beijing 100035 Peoples R China;

    Northeastern Univ Sch Mat Sci & Engn Key Lab Anisotropy & Texture Mat Educ Minist China Shenyang 110819 Peoples R China|Northeastern Univ Res Ctr Met Wires Shenyang 110819 Peoples R China;

    Beijing Jishuitan Hosp Beijing Res Inst Orthopaed & Traumatol Lab Bone Tissue Engn Beijing Lab Biomed Mat Beijing 100035 Peoples R China;

    Northeastern Univ Sch Mat Sci & Engn Key Lab Anisotropy & Texture Mat Educ Minist China Shenyang 110819 Peoples R China|Northeastern Univ Res Ctr Met Wires Shenyang 110819 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Titanium-copper alloy; Ultrasonic micro-arc oxidation; Antibacterial property; Cell compatibility; Ti-Cu alloy;

    机译：钛铜合金;超声波微弧氧化;抗菌性质;细胞相容性;Ti-Cu合金;

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