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首页> 外文期刊>Materials science & engineering >Swelling and diffusion characteristics of modified poly (N-isopropylacrylamide) hydrogels
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Swelling and diffusion characteristics of modified poly (N-isopropylacrylamide) hydrogels

机译：改性聚（N-异丙基丙烯酰胺）水凝胶的溶胀和扩散特性

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摘要

Thermo-responsive hydrogels are capable of swelling changes to external temperature. A series of modified poly (N-isopropylacrylamide) (PNIPA) hydrogels was synthesized by free radical polymerization in aqueous solution. Acrylamide (AAm) was used to increase the lower critical solution temperature (LCST), while sodium alginate (SA) was used to improve the swelling performance of the hydrogels. Experiments show that 5.5% mass ratio of Mm increased the LCST by about 9 ℃ above that of conventional PNIPA. Also, SA significantly improved the equilibrium swelling ratio associate with temperature change. Trypan blue diffusion revealed significant differences in the fluid release obtained from hydrogels with modified LCST and swelling properties. The implications of the modified fluid release and swelling characteristics are also discussed for the device design of thermo-sensitive hydrogels for localized drug delivery.
机译：热响应水凝胶能够溶胀外部温度。通过水溶液中的自由基聚合反应合成了一系列改性的聚（N-异丙基丙烯酰胺）（PNIPA）水凝胶。丙烯酰胺（AAm）用于提高较低的临界溶液温度（LCST），而藻酸钠（SA）用于改善水凝胶的溶胀性能。实验表明，Mm的质量比为5.5％时，LCST的含量比常规PNIPA提高了约9℃。而且，SA显着改善了与温度变化相关的平衡溶胀率。锥虫蓝扩散表明，从具有改良的LCST和溶胀特性的水凝胶中获得的液体释放具有显着差异。对于用于局部药物递送的热敏水凝胶的装置设计，还讨论了改良的液体释放和溶胀特性的含义。

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  • 来源
    《Materials science & engineering》 |2010年第1期|8-13|共6页
  • 作者

    G. Fu; W.O. Soboyejo;

  • 作者单位

    Princeton Institute for the Science and Technology of Materials (PRISM). 70 Prospect Street. Princeton, NJ 08544. USA The Department of Mechanical and Aerospace Engineering. Princeton University, Olden Street. Princeton, NJ 08544, USA;

    Princeton Institute for the Science and Technology of Materials (PRISM). 70 Prospect Street. Princeton, NJ 08544. USA The Department of Mechanical and Aerospace Engineering. Princeton University, Olden Street. Princeton, NJ 08544, USA;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    poly (N-isopropylacrylamide); thermo-responsive hydrogel; diffusion; swelling; trypan blue; drug delivery;

    机译：聚（N-异丙基丙烯酰胺）;热响应水凝胶;扩散;肿胀;台盼蓝药物输送;

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