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首页> 外文期刊>Materials science & engineering >Feasibility study of silica sol as the carrier of a hydrophobic drug in aqueous solution using enrofloxacin as the model
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Feasibility study of silica sol as the carrier of a hydrophobic drug in aqueous solution using enrofloxacin as the model

机译：以恩诺沙星为模型的硅溶胶为水溶液中疏水性药物载体的可行性研究

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摘要

The aim of this study was to determine the feasibility of using silica sol to carry a hydrophobic drug in aqueous solution. Enrofloxacin, which was selected as the model drug because it is a broad-spectrum antibiotic drug with poor solubility in water, was adsorbed onto silica sol in aqueous solution during cooling from 60℃ to room temperature. The drug-loaded silica sol was characterized by transmission electron microscopy, Fourier transform infrared spectrum, thermal gravimetric analysis and ultraviolet-visible light spectroscopy. The results showed that enrofloxacin was adsorbed by silica sol without degradation at a loading of 15.23wt.%. In contrast to the rapid release from pure enrofloxacin, the drug-loaded silica sol showed a slower release over a longer time. Kinetics analysis suggested the drug release from silica sol was mainly a diffusion-controlled process. Therefore, silica sol can be used to carry a hydrophobic drug in aqueous solution for controlled drug delivery.
机译：这项研究的目的是确定使用硅溶胶在水溶液中携带疏水性药物的可行性。由于恩诺沙星是一种广谱抗生素药物，在水中的溶解性较差，因此被选作模型药物，在从60℃冷却至室温的过程中，它被水溶液吸附在硅溶胶上。通过透射电子显微镜，傅立叶变换红外光谱，热重分析和紫外可见光光谱对载药的硅溶胶进行了表征。结果表明，恩诺沙星在15.23wt。％的负载下被二氧化硅溶胶吸附而没有降解。与从纯恩诺沙星快速释放相反，载有药物的硅溶胶在更长的时间内显示出较慢的释放。动力学分析表明从硅溶胶中释放的药物主要是扩散控制的过程。因此，硅溶胶可用于在水溶液中携带疏水性药物，以控制药物的输送。

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  • 来源
    《Materials science & engineering》 |2010年第1期|58-61|共4页
  • 作者

    Meirong Song; Junling Song; Aimin Ning; Baoan Cui; Shumin Cu; Yaobing Zhou; Wankai An; Xuesong Dong; Gege Zhang;

  • 作者单位

    College of Sciences, Henan Agricultural University, Zhengzhou 450002, PR China;

    School of Food, Henan Institute of Science and Technology, Xinxiang, 453003, PR China;

    College of Sciences, Henan Agricultural University, Zhengzhou 450002, PR China;

    College of Sciences, Henan Agricultural University, Zhengzhou 450002, PR China;

    College of Sciences, Henan Agricultural University, Zhengzhou 450002, PR China;

    College of Sciences, Henan Agricultural University, Zhengzhou 450002, PR China;

    College of Sciences, Henan Agricultural University, Zhengzhou 450002, PR China;

    College of Sciences, Henan Agricultural University, Zhengzhou 450002, PR China;

    College of Sciences, Henan Agricultural University, Zhengzhou 450002, PR China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    silica sol; enrofloxacin; controlled release;

    机译：硅溶胶恩诺沙星控释;

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