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首页> 外文期刊>Materials science & engineering >Calcium phosphate coating containing silver shows high antibacterial activity and low cytotoxicity and inhibits bacterial adhesion
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Calcium phosphate coating containing silver shows high antibacterial activity and low cytotoxicity and inhibits bacterial adhesion

机译：含银的磷酸钙涂层显示出高抗菌活性和低细胞毒性，并抑制细菌粘附

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摘要

Surgical site infection is one of the serious complications of orthopedic implants. In order to reduce the incidence of implant-associated infections, we developed a novel coating technology of calcium phosphate (CP) containing silver (Ag), designated Ag-CP coating, using a thermal spraying technique. In this study, we evaluated the antibacterial efficacy and biological safety of this coating. In vitro antibacterial activity tests showed that the growths of Escherichia coli, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) are completely suppressed on Ag-CP coating. In vitro bacterial adherence tests revealed that the number of adherent bacteria on the surface of this coating is significantly less (p<0.02) than that on the surface of the CP coating. Moreover, the Ag-CP coating completely inhibits MRSA adhesion [<10 colony-forming units (CFU)] when 10~2 CFU MRSA is inoculated. On the other hand, V79 Chinese hamster lung cells were found to grow on the Ag-CP coating as well as on the CP coating in a cytotoxicity test. These results indicate that the Ag-CP coating on the surface of orthopedic implants exhibits antibacterial activity and inhibits bacterial adhesion without cytotoxicity.
机译：手术部位感染是整形外科植入物的严重并发症之一。为了减少植入物相关感染的发生率，我们使用热喷涂技术开发了一种新型的含银（Ag）的磷酸钙（CP）涂层技术，称为Ag-CP涂层。在这项研究中，我们评估了这种涂层的抗菌功效和生物安全性。体外抗菌活性测试表明，在Ag-CP涂层上完全抑制了大肠杆菌，金黄色葡萄球菌和耐甲氧西林的金黄色葡萄球菌（MRSA）的生长。体外细菌粘附测试表明，该涂层表面的粘附细菌数量明显少于CP涂层表面的粘附细菌数量（p <0.02）。此外，当接种10〜2 CFU MRSA时，Ag-CP涂层会完全抑制MRSA粘附[<10个菌落形成单位（CFU）]。另一方面，在细胞毒性试验中，发现V79中国仓鼠肺细胞在Ag-CP涂层和CP涂层上生长。这些结果表明，整形外科植入物表面上的Ag-CP涂层表现出抗菌活性，并抑制细菌粘附而无细胞毒性。

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  • 来源
    《Materials science & engineering》 |2010年第1期|175-180|共6页
  • 作者

    Yoshiki Ando; Hiroshi Miyamoto; Iwao Noda; Nobuko Sakurai; Tomonori Akiyama; Yutaka Yonekura; Takafumi Shimazaki; Masaki Miyazaki; Masaaki Mawatari; Takao Hotokebuchi;

  • 作者单位

    Division of Microbiology, Department of Pathology and Microbiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan Research Department, Japan Medical Materials Corporation, Uemura Nissei Bldg.9F 3-3-31 Miyahara, Yodogawa-ku, Osaka 532-0003, Japan;

    Division of Microbiology. Department of Pathology and Microbiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan;

    Research Department, Japan Medical Materials Corporation, Uemura Nissei Bldg.9F 3-3-31 Miyahara, Yodogawa-ku, Osaka 532-0003, Japan;

    Research Department, Japan Medical Materials Corporation, Uemura Nissei Bldg.9F 3-3-31 Miyahara, Yodogawa-ku, Osaka 532-0003, Japan;

    Division of Microbiology. Department of Pathology and Microbiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan;

    Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Uabeshima, Saga 849-8501, Japan;

    Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Uabeshima, Saga 849-8501, Japan;

    Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Uabeshima, Saga 849-8501, Japan;

    Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Uabeshima, Saga 849-8501, Japan;

    Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, 5-1-1 Uabeshima, Saga 849-8501, Japan;

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  • 正文语种 eng
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  • 关键词

    infection; antibacterial; bacterial adherence; cytotoxicity; orthopaedic implant;

    机译：感染;抗菌;细菌粘附细胞毒性骨科植入物;

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