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首页> 外文期刊>Materials science & engineering >Dissolution behavior and bioactivity study of glass ceramic scaffolds in the system of CaO-P_2O_5-Na_2O-ZnO prepared by sol-gel technique
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Dissolution behavior and bioactivity study of glass ceramic scaffolds in the system of CaO-P_2O_5-Na_2O-ZnO prepared by sol-gel technique

机译：溶胶-凝胶法制备CaO-P_2O_5-Na_2O-ZnO体系中玻璃陶瓷支架的溶解行为和生物活性研究

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摘要

Three-dimensional glass ceramic scaffolds from the system CaO-P_2O_5-Na_2O-ZnO have been prepared by coating polyurethane foams with sol-gel derived glass slurry. Main phase catena hexaphosphate (Ca_4P_6O_(19)), minor phases calcium pyrophosphate (β-Ca_2P_2O_7) and calcium metaphosphate (β-Ca(PO_3)_2) were detected in the prepared glass ceramics. In order to assess the potential use in hard tissue engineering, the dissolution and precipitation behavior of the glass ceramics was investigated in vitro after soaking in simulated body fluid (SBF) for different periods of time, and the bioactivity and biocompatibility studies were conducted using mouse MC3T3-E1. Ca_4P_6O_(19) phase showed a good chemical durability in SBF solution over the period time of soaking. However, there were small quantities of apatite-like deposits formed on the surfaces after soaking 28 days, exhibiting a poor ability of inducing calcification in SBF. In vitro cell culture, a high degree of cell adhesion and spreading was achieved and large number of mineralized deposits composed of Ca, P and Zn were detected in these porous scaffolds. These results confirmed the biocompatibility and bioactivity of the glass ceramics and the positive effects on mouse MC3T3-E1 cell behavior although no continuous apatite layer was formed on scaffold surfaces after soaking in SBF, and also demonstrated that Zn doped this glass ceramics could strongly stimulate the formation of mineralized deposits in vitro culture of MC3T3-E1 cells.
机译：由CaO-P_2O_5-Na_2O-ZnO系统制备的三维玻璃陶瓷支架是通过用溶胶-凝胶衍生的玻璃浆料涂覆聚氨酯泡沫材料而制备的。在制得的玻璃陶瓷中检测到主相六磷酸Caena（4P_6O_（19）），次相焦磷酸钙（β-Ca_2P_2O_7）和偏磷酸钙（β-Ca（PO_3）_2）。为了评估在硬组织工程中的潜在用途，在不同时间浸泡在模拟体液（SBF）中后，体外研究了玻璃陶瓷的溶解和沉淀行为，并使用小鼠进行了生物活性和生物相容性研究MC3T3-E1。在浸泡期间，Ca_4P_6O_（19）相在SBF溶液中显示出良好的化学耐久性。但是，浸泡28天后，在表面上形成了少量磷灰石样沉积物，显示出SBF诱导钙化的能力较弱。在体外细胞培养中，实现了高度的细胞粘附和扩散，并且在这些多孔支架中检测到大量由Ca，P和Zn组成的矿化沉积物。这些结果证实了玻璃陶瓷的生物相容性和生物活性以及对小鼠MC3T3-E1细胞行为的积极影响，尽管在SBF中浸泡后在支架表面没有形成连续的磷灰石层，并且还证明了掺杂Zn可以强烈刺激玻璃陶瓷。体外培养MC3T3-E1细胞形成矿化沉积物。

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  • 来源
    《Materials science & engineering》 |2010年第1期|105-111|共7页
  • 作者

    Cai Shu; Zhang Wenjuan; Guohua Xu; Zhou Wei; Jiang Wei; Wang Dongmei;

  • 作者单位

    Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, People's Republic of China;

    Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, People's Republic of China;

    Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, People's Republic of China Shanghai Changzheng Hospital, Shanghai 200003, People's Republic of China;

    Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, People's Republic of China;

    Shanghai Changzheng Hospital, Shanghai 200003, People's Republic of China;

    Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, People's Republic of China;

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  • 正文语种 eng
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  • 关键词

    class ceramic scaffolds; Ca_4P_6O_(19); degradation; mineralization; bioactivity;

    机译：陶瓷脚手架;Ca_4P_6O_（19）;降解;矿化生物活性;

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