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首页> 外文期刊>Materials science & engineering >Improvement in the morphology of micro-arc oxidised titanium surfaces: A new process to increase osteoblast response
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Improvement in the morphology of micro-arc oxidised titanium surfaces: A new process to increase osteoblast response

机译：改善微弧氧化钛表面的形态：增加成骨细胞反应的新工艺

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摘要

This study describes a method for combining sandblast-acid etching and micro-arc oxidation to optimise titanium implant surfaces, and examines the effects of these surfaces on osteoblast response. Titanium discs were grouped as: micro-arc oxidised (MAO), sandblast-acid etched and micro-arc oxidised (MAO-SA), micro-arc oxidised and heated (MAO-HT), and untreated smooth surface. The combination of sandblast-acid etching and micro-arc oxidation in the MAO-SA group created an average surface roughness of 2.02 ± 0.15 μm compared to the untreated machined surface of 0.31 ± 0.06 μm. Scanning electron microscopy observations of the surface structures showed that the irregularly ordered valleys created by sandblast-acid etching remained after micro-arc oxidation and that micropores had also formed. These microstructures provided a better place for osteoblasts to spread compared with the other surfaces. In addition, our results indicated that adherent osteoblasts expressed greater alkaline phosphatase (ALP) activity and osteocalcin (OC) production on MAO-SA surfaces compared with MAO, MAO-HT, and smooth surfaces. The overall results clearly indicate that combining sandblast-acid etching and micro-arc oxidation techniques improves the titanium surface morphology and increases the roughness, which provides an optimal surface for cell differentiation and osseointegration.
机译：这项研究描述了一种结合喷砂酸蚀刻和微弧氧化来优化钛植入物表面的方法，并研究了这些表面对成骨细胞反应的影响。钛圆盘分为：微弧氧化（MAO），喷砂酸蚀刻和微弧氧化（MAO-SA），微弧氧化和加热（MAO-HT）和未处理的光滑表面。与未经处理的机加工表面0.31±0.06μm相比，MAO-SA组中喷砂酸蚀刻和微弧氧化的结合产生了2.02±0.15μm的平均表面粗糙度。扫描电子显微镜对表面结构的观察表明，微弧氧化后，由喷砂酸腐蚀产生的不规则有序的凹谷仍然存在，并且还形成了微孔。与其他表面相比，这些微结构为成骨细胞的扩散提供了更好的位置。此外，我们的结果表明，与MAO，MAO-HT和光滑表面相比，粘附的成骨细胞在MAO-SA表面表达的碱性磷酸酶（ALP）活性和骨钙素（OC）的产量更高。总体结果清楚地表明，结合喷砂酸蚀刻和微弧氧化技术可改善钛的表面形态并增加粗糙度，从而为细胞分化和骨整合提供最佳的表面。

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  • 来源
    《Materials science & engineering》 |2010年第1期|141-147|共7页
  • 作者

    Feilong Deng; Weizhen Zhang; Peifen Zhang; Chenhan Liu; Junqi Ling;

  • 作者单位

    Guanghua College of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510080, China;

    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109-0346, USA;

    Guanghua College of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510080, China;

    Guanghua College of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510080, China;

    Department of Oral Implantology, Guanghua College of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510080, China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    sandblast; acid etch; micro-arc oxidation; titanium; osteoblasts; cell viability;

    机译：喷沙;酸蚀微弧氧化钛;成骨细胞细胞活力;

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