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首页> 外文期刊>Materials science & engineering >Fabrication of a composite vascular scaffold using electrospinning technology
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Fabrication of a composite vascular scaffold using electrospinning technology

机译：使用静电纺丝技术制造复合血管支架

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摘要

Intermolecular forces and morphology demonstrated that there was an excellent compatibility between silk fibroin and gelatin. The silk fibroin/gelatin composite vascular scaffold (inner diameter 4.5 mm) was prepared successfully by electrospinning. The scaffold was treated with ethanol to enhance the water-resistant ability and biomechanical properties. After ethanol treatment, the scaffold could hardly dissolve in the water, and FTIR showed that the conformation of the treated silk fibroin/gelatin composite vascular scaffold was mainly β-sheets. The electrospun silk fibroin/gelatin vascular scaffold possessed outstanding biomechanical properties. In vitro cell culture and in vivo subcutaneous implantation demonstrated that the electrospun silk fibroin/gelatin vascular scaffold had an appropriate biocompatibility. The results indicated that the electrospun silk fibroin/gelatin composite vascular scaffold could be considered as an ideal candidate for tissue-engineered blood vessel.
机译：分子间的力和形态表明，丝素蛋白和明胶之间具有极好的相容性。通过静电纺丝成功地制备了丝素蛋白/明胶复合血管支架（内径4.5 mm）。支架用乙醇处理，以增强其抗水能力和生物力学性能。乙醇处理后，该支架几乎不溶于水，并且FTIR显示经处理的丝纤蛋白/明胶复合血管支架的构象主要是β-折叠。电纺丝素蛋白/明胶血管支架具有出色的生物力学性能。体外细胞培养和体内皮下植入证明，电纺丝素蛋白/明胶血管支架具有适当的生物相容性。结果表明，电纺丝素蛋白/明胶复合血管支架可以被认为是组织工程血管的理想候选者。

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  • 来源
    《Materials science & engineering》 |2010年第5期|p.670-676|共7页
  • 作者

    Shu-Dong Wang; You-Zhu Zhang; Gui-Bo Yin; Hong-Wei Wang; Zhi-Hui Dong;

  • 作者单位

    Department of Textile Engineering, Yancheng Textile Vocational Technology College, 265 South Jiefang Road, Yancheng 224005, China;

    College of Textile and Clothing Engineering, Soochow University, 178 East Ganjiang Road, Suzhou 215021, China;

    College of Textile and Clothing Engineering, Soochow University, 178 East Ganjiang Road, Suzhou 215021, China;

    College of Textile and Clothing Engineering, Soochow University, 178 East Ganjiang Road, Suzhou 215021, China;

    Department of Vascular Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    electrospinning; silk fibroin; vascular scaffold; intermolecular force; biocompatibility;

    机译：电纺;丝素蛋白;血管支架分子间力生物相容性;

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