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首页> 外文期刊>Materials science & engineering >Electrochemical study of atenolol at a carbon paste electrode modified with mordenite type zeolite
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Electrochemical study of atenolol at a carbon paste electrode modified with mordenite type zeolite

机译：丝光沸石型沸石修饰碳糊电极上阿替洛尔的电化学研究

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摘要

The electrochemical behavior of atenolol (ATN) at the surface of a carbon paste electrode modified with mordenite zeolite (MOR-MCPE) is described. The prepared electrode shows a good electrocatalytic activity toward the oxidation of atenoiol, which is leading to considerable improvement of sensitivity (anodic current). Whereas at the surface of unmodified electrode an electrochemical activity for atenolol cannot be observed, a sharp anodic wave is obtained using the prepared modified electrode. The mechanism of oxidation of ATN at the surface of the MOR-MCPE containing various percents of mordenite is thoroughly investigated by cyclic and differential pulse voltammetry. Acetate, hydrogen phosphate and ammonium buffers were tested as the supporting electrolyte to find the optimal pH value. The optimal pH value was 5.0 for acetate buffer. A linear voltammetric response for ATN was obtained in the concentration range of 0.4 to 80 μM with a slope of 0.676 μA/μM. The LOD and LOQ of the electrode were 0.1 μM (26.6 ug/L) and 0.35 μM (93.1 ug/L), respectively. The results obtained for ATN in pharmaceutical formulations (tablets) was in agreement with compared reference method. In conclusion, this study has illustrated that the proposed electrode modified with mordenite is suitable for selective measurements of ATN.
机译：描述了Atenolol（ATN）在用丝光沸石（MOR-MCPE）改性的碳糊电极表面的电化学行为。制备的电极显示出对烯醇的良好的电催化活性，这导致灵敏度（阳极电流）的显着提高。尽管在未修饰的电极的表面不能观察到对阿替洛尔的电化学活性，但是使用所制备的修饰的电极获得了尖锐的阳极波。通过循环和差分脉冲伏安法深入研究了含有不同百分比的丝光沸石的MOR-MCPE表面ATN的氧化机理。测试乙酸盐，磷酸氢盐和铵缓冲液作为支持电解质，以找到最佳的pH值。醋酸盐缓冲液的最佳pH值为5.0。在0.4至80μM的浓度范围内获得的ATN线性伏安响应具有0.676μA/μM的斜率。电极的LOD和LOQ分别为0.1μM（26.6 ug / L）和0.35μM（93.1 ug / L）。药物制剂（片剂）中ATN的结果与比较参考方法一致。总之，这项研究表明拟用丝光沸石修饰的电极适用于ATN的选择性测量。

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