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The effect of annealing and gold deposition on the performance of magnetoelastic biosensors

机译：退火和金沉积对磁弹性生物传感器性能的影响

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摘要

Magnetoelastic materials have a mass-sensitive, characteristic, resonant frequency that make them an ideal choice for application as the platform for a biosensor. The biosensor is formed by immobilizing a bio-molecular recognition element directly onto the surface of the magnetoelastic material. When exposed to the analyte, this bio-molecular recognition element binds the target species (spore or bacteria of interest), thereby increasing the mass and decreasing the resonance frequency of the sensor. This change in characteristic resonance frequency can be determined by monitoring remotely the magnetic flux in response to an applied, time varying, magnetic field with a pick-up coil. However, the environmental stability and bioactivity of the biosensor platform material are very important to performance of the overall biosensor. This research investigates the effects of annealing and deposition of a gold layer on the environmental stability and detection sensitivity of a magnetoelastic biosensor platform. The results show that deposition of a gold layer by sputtering additionally improved bioreactivity while maintaining a balance of environmental stability and detection sensitivity. Two annealing steps in a vacuum oven, one before and one after gold deposition, can effectively increase the magnetoelastic platform's environmental stability, as well as the Q-factor of the resonance signal.
机译：磁弹性材料具有对质量敏感的特性，谐振频率，使其成为用作生物传感器平台的理想选择。通过将生物分子识别元件直接固定在磁弹性材料的表面上来形成生物传感器。当暴露于分析物时，该生物分子识别元件会结合目标物种（感兴趣的孢子或细菌），从而增加质量并降低传感器的共振频率。可以通过响应于通过拾波线圈施加的随时间变化的磁场远程监视磁通量来确定特征谐振频率的这种变化。然而，生物传感器平台材料的环境稳定性和生物活性对于整个生物传感器的性能非常重要。这项研究调查了金层的退火和沉积对磁弹性生物传感器平台的环境稳定性和检测灵敏度的影响。结果表明，通过溅射沉积金层还改善了生物反应性，同时保持了环境稳定性和检测灵敏度之间的平衡。在真空炉中进行两个退火步骤，一个在金沉积之前，一个在金沉积之后，可以有效地提高磁弹性平台的环境稳定性以及共振信号的Q因子。

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