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首页> 外文期刊>Materials science & engineering. C, Biomimetic and supramolecular systems >Immobilization of chitosan gel with cross-linking reagent on PNIPAAm gel/PP nonwoven composites surface
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Immobilization of chitosan gel with cross-linking reagent on PNIPAAm gel/PP nonwoven composites surface

机译：用交联剂将壳聚糖凝胶固定在PNIPAAm凝胶/ PP非织造复合材料表面

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摘要

This study was to immobilize chitosan (CS), which is a biodegradable and antibacterial polymer, on poly(N-isopropylacrylamide) (PNIPAAm) gel/polypropylene (PP) nonwoven composites surface for wound dressing applications. PP nonwoven has been extensively used due to its porosity, allowing ventilation, high surface area and excellent mechanical properties. However, the hydrophobic surface of PP nonwoven limits its applications; in this study, we used the plasma-activation treatment and subsequently UV-light graft polymerization of NIPAAm gel to improve its hydrophilicity. Chitosan was immobilized onto PNIPAAm gel/PP nonwoven composites surface using the cross-linking agent, glutaraldehyde (GA). This complex was characterized by scanning electron microscopy (SEM). The results indicated that the wettability of the composite was improved after plasma treatment and photo-induced graft polymerization and chitosan was successfully immobilized onto the surface of PNIPAAm gel/PP nonwoven composites through cross-linking process. Finally, the preliminary result shows that chitosan hydrogels displayed antibacterial ability to Escherichia coli and Staphylococcus aureus. The (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) (MTT) method indicated that the porous chitosan sponge exhibited good biocompatibility to fibroblast cells.
机译：这项研究旨在将壳聚糖（CS）固定在聚（N-异丙基丙烯酰胺）（PNIPAAm）凝胶/聚丙烯（PP）非织造复合材料表面上，这是一种可生物降解和抗菌的聚合物，用于伤口敷料应用。 PP无纺布由于其多孔性，允许通风，高表面积和出色的机械性能而被广泛使用。但是，PP无纺布的疏水性表面限制了其应用。在这项研究中，我们使用了等离子体活化处理以及随后的NIPAAm凝胶紫外光接枝聚合反应，以提高其亲水性。使用交联剂戊二醛（GA）将壳聚糖固定在PNIPAAm凝胶/ PP非织造复合材料表面上。该复合物通过扫描电子显微镜（SEM）表征。结果表明，经过等离子处理和光诱导接枝聚合反应后，复合材料的润湿性得到改善，并且壳聚糖通过交联过程成功地固定在PNIPAAm凝胶/ PP非织造复合材料的表面上。最后，初步结果表明，壳聚糖水凝胶对大肠杆菌和金黄色葡萄球菌具有抗菌能力。 （3-（4,5-二甲基噻唑基-2）-2，5-二苯基四唑溴化物）（MTT）方法表明，多孔壳聚糖海绵对成纤维细胞具有良好的生物相容性。

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