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首页> 外文期刊>Materials science & engineering >Simultaneous engineering of nanofillers and patterned surface macropores of graphene/hydroxyapatite/polyetheretherketone ternary composites for potential bone implants
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Simultaneous engineering of nanofillers and patterned surface macropores of graphene/hydroxyapatite/polyetheretherketone ternary composites for potential bone implants

机译：石墨烯/羟基磷灰石/聚醚醚酮三农素复合材料的纳米填料和图案化表面大孔的同时工程，用于潜在骨植入物

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摘要

Incorporating bioactive nanofillers and creating porous surfaces are two common strategies used to improve the tissue integration of polyetheretherketone (PEEK) material. However, few studies have reported the combined use of both strategies to modify PEEK. Herein, for the first time, dual nanoparticles of graphene oxide (GO) and hydroxyapatite (HAp) were incorporated into PEEK matrix to obtain ternary composites that were laser machined to create macropores with diameters ranging from 200 ?m to 600 ?m on the surfaces. The surface morphology and chemistry, mechanical properties, and cellular responses of the composites were investigated. The results show that micropatterned pores with a depth of 50 ?m were created on the surfaces of the composites, which do not significantly affect the mechanical properties of the resultant composites. More importantly, the incorporation of GO and HAp significantly improves the cell adhesion and proliferation on the surface of PEEK. Compared to the smooth surface composite, the composites with macroporous surface exhibit markedly enhanced cell viability. The combined use of nanofillers and surface macropores may be a promising way of improving tissue integration of PEEK for bone implants.
机译：掺入的生物活性纳米填料和创建多孔表面是用来改善聚醚醚酮（PEEK）材料的组织整合两种常见的策略。然而，很少有研究报道联合使用两种策略来修改PEEK。这里，对于第一次，石墨烯氧化物（GO）和羟基磷灰石（HAP）的双纳米颗粒掺入到PEEK矩阵，以获得进行激光加工以产生具有直径范围为200？m至600？的表面上米的大孔三元复合材料。表面形态和化学，机械性能，和复合材料的细胞应答进行了研究。结果表明，微图案化的孔具有50？米深度的复合材料的表面，其不显著影响所得复合材料的机械性能上创建。更重要的是，GO和HAP的掺入显著提高PEEK的表面上的细胞粘附和增殖。相比光滑表面复合材料，大孔表面表现出复合材料显着增强细胞生存力。组合使用纳米填料和表面大孔可以是提高PEEK的组织整合为骨植入物的一个有希望的途径。

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  • 来源
    《Materials science & engineering》 |2021年第4期|111967.1-111967.8|共8页
  • 作者

    Huang Zhihuan; Wan Yizao; Zhu Xiangbo; Zhang Peibiao; Yang Zhiwei; Yao Fanglian; Luo Honglin;

  • 作者单位

    East China Jiaotong Univ Inst Adv Mat Jiangxi Key Lab Nanobiomat Nanchang 330013 Jiangxi Peoples R China;

    East China Jiaotong Univ Inst Adv Mat Jiangxi Key Lab Nanobiomat Nanchang 330013 Jiangxi Peoples R China|Tianjin Univ Sch Mat Sci & Engn Tianjin 300072 Peoples R China;

    East China Jiaotong Univ Inst Adv Mat Jiangxi Key Lab Nanobiomat Nanchang 330013 Jiangxi Peoples R China;

    Chinese Acad Sci Changchun Inst Appl Chem Changchun 130022 Peoples R China;

    East China Jiaotong Univ Inst Adv Mat Jiangxi Key Lab Nanobiomat Nanchang 330013 Jiangxi Peoples R China;

    Tianjin Univ Sch Chem Engn & Technol Key Lab Syst Bioengn Minist Educ Tianjin 300072 Peoples R China;

    East China Jiaotong Univ Inst Adv Mat Jiangxi Key Lab Nanobiomat Nanchang 330013 Jiangxi Peoples R China|Tianjin Univ Sch Mat Sci & Engn Tianjin 300072 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Graphene oxide; Hydroxyapatite; Polyetheretherketone; Porous surface; Bone implant;

    机译：石墨烯;羟基磷灰石;聚醚醚酮;多孔表面;骨植入物;

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