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Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer

机译：多官能聚合物胶束纳米医生在癌症的诊断和治疗中

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摘要

Polymeric micelles are a prevalent topic of research for the past decade, especially concerning their fitting ability to deliver drug and diagnostic agents. This delivery system offers outstanding advantages, such as biocompatibility, high loading efficiency, water-solubility, and good stability in biological fluids, to name a few. The multifunctional polymeric micellar architect offers the added capability to adapt its surface to meet the lookedfor clinical needs. This review cross-talks the recent reports, proof-of-concept studies, patents, and clinical trials that utilize polymeric micellar family architectures concerning cancer targeted delivery of anticancer drugs, gene therapeutics, and diagnostic agents. The manuscript also expounds on the underlying opportunities, allied challenges, and ways to resolve their bench-to-bedside translation for allied clinical applications.
机译：聚合物胶束是过去十年的一种普遍存在的研究题目，特别是关于其拟合递送药物和诊断剂的能力。 这个送货系统提供出色的优点，如生物相容性，高负荷效率，水溶性和生物流体的良好稳定性，以命名为几个。 多功能聚合物胶束架构师提供了适应其表面以满足寻找临床需求的添加能力。 本综述交叉谈论最近的报告，概念验证研究，专利和临床试验，所述癌症患者患有抗癌药物，基因治疗剂和诊断剂的聚合物胶束家族架构。 稿件还阐述了潜在的机会，盟军挑战，以及解决依赖临床应用的卧板到床边翻译的方法。

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  • 来源
    《Materials science & engineering》 |2021年第7期|112186.1-112186.41|共41页
  • 作者

    Raval Nidhi; Maheshwari Rahul; Shukla Havish; Kalia Kiran; Torchilin Vladimir P.; Tekade Rakesh K.;

  • 作者单位

    Govt India Natl Inst Pharmaceut Educ & Res NIPER Ahmedabad Inst Natl Importance Opposite Air Force Stn Palaj Gandhinagar 382355 Gujarat India;

    Govt India Natl Inst Pharmaceut Educ & Res NIPER Ahmedabad Inst Natl Importance Opposite Air Force Stn Palaj Gandhinagar 382355 Gujarat India|Green Pharma Ind Pk Sch Pharm & Technol Management SVKMS NMIMS Hyderabad 509301 India;

    Govt India Natl Inst Pharmaceut Educ & Res NIPER Ahmedabad Inst Natl Importance Opposite Air Force Stn Palaj Gandhinagar 382355 Gujarat India;

    Govt India Natl Inst Pharmaceut Educ & Res NIPER Ahmedabad Inst Natl Importance Opposite Air Force Stn Palaj Gandhinagar 382355 Gujarat India;

    Northeastern Univ Sch Pharm Dept Pharmaceut Sci Bouve Coll Hlth Sci 140 Fenway 360 Huntington Ave Boston MA 02115 USA|Sechenov Univ Dept Oncol Radiotherapy & Plast Surg IM Sechenov First Moscow State Med Univ Moscow Russia;

    Govt India Natl Inst Pharmaceut Educ & Res NIPER Ahmedabad Inst Natl Importance Opposite Air Force Stn Palaj Gandhinagar 382355 Gujarat India;

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  • 正文语种 eng
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  • 关键词

    Polymeric micelles; Multifunctional polymeric micelles; Drug delivery; Diagnosis; Clinical trials;

    机译：聚合物胶束;多官能聚合物胶束;药物递送;诊断;临床试验;

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