Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends

Karakurt Ilkay; Ozaltin Kadir; Vargun Elif; Kucerova Liliana; Suly Pavol; Harea Evghenii; Minarik Antonin; Stepankova Katerina; Lehocky Marian; Humpolicek Petr; Vesel Alenka; Mozetic Miran

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Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends

机译：通过香草蛋白交联壳聚糖 - 聚乙烯醇共混物控制瑞氧氟沙星的控制释放

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摘要

In transdermal drug delivery applications uniform drug distribution and sustained release are of great importance to decrease the side effects. In this direction in the present research, vanillin crosslinked chitosan (CS) and polyvinyl alcohol (PVA) blend based matrix-type transdermal system was prepared by casting and drying of aqueous solutions for local delivery of enrofloxacin (ENR) drug. Subsequently, the properties including the morphology, chemical structure, thermal behavior, tensile strength, crosslinking degree, weight uniformity, thickness, swelling and drug release of the CS-PVA blend films before and after crosslinking were characterized. In vitro drug release profiles showed the sustained release of ENR by the incorporation of vanillin as a crosslinker into the CS-PVA polymer matrix. Furthermore, the release kinetic profiles revealed that the followed mechanism for all samples was Higuchi and the increase of vanillin concentration in the blend films resulted in the change of diffusion mechanism from anomalous transport to Fickian diffusion. Overall, the obtained results suggest that the investigated vanillin crosslinked CS-PVA matrix-type films are potential candidates for transdermal drug delivery system.

机译：在透皮药物递送应用中，均匀的药物分布和持续的释放是重视降低副作用。在本研究中，通过铸造和干燥局部递送富含氧氟沙星（ENR）药物的水溶液，制备Vanillin交联壳聚糖（Cs）和聚乙烯醇（PVA）混合物基基质透皮系统。随后，表征了在交联之前和之后CS-PVA共混膜的形态，化学结构，热行为，拉伸强度，交联度，重量均匀性，厚度，溶胀和药物释放的性质。体外药物释放型材通过将香草蛋白作为交联剂掺入CS-PVA聚合物基质的持续释放。此外，释放动力学曲线揭示了所有样品的遵循机制是HIGUCHI，并且共混膜中的香草蛋白浓度的增加导致从异常运输到Fickian扩散的扩散机制的变化。总体而言，所得结果表明研究的香草蛋白交联的CS-PVA基质型膜是用于透皮药物递送系统的潜在候选者。

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来源
《Materials science & engineering》 |2021年第7期|112125.1-112125.13|共13页
作者
Karakurt Ilkay; Ozaltin Kadir; Vargun Elif; Kucerova Liliana; Suly Pavol; Harea Evghenii; Minarik Antonin; Stepankova Katerina; Lehocky Marian; Humpolicek Petr; Vesel Alenka; Mozetic Miran;
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作者单位

Tomas Bata Univ Zlin Univ Inst Ctr Polymer Syst Trida Tomase Bati 5678 Zlin 76001 Czech Republic;

Tomas Bata Univ Zlin Univ Inst Ctr Polymer Syst Trida Tomase Bati 5678 Zlin 76001 Czech Republic;

Tomas Bata Univ Zlin Univ Inst Ctr Polymer Syst Trida Tomase Bati 5678 Zlin 76001 Czech Republic|Mugla Sitki Kocman Univ Dept Chem TR-48000 Kotekli Mugla Turkey;

Tomas Bata Univ Zlin Univ Inst Ctr Polymer Syst Trida Tomase Bati 5678 Zlin 76001 Czech Republic;

Tomas Bata Univ Zlin Univ Inst Ctr Polymer Syst Trida Tomase Bati 5678 Zlin 76001 Czech Republic;

Tomas Bata Univ Zlin Univ Inst Ctr Polymer Syst Trida Tomase Bati 5678 Zlin 76001 Czech Republic|Tomas Bata Univ Zlin Fac Technol Vavreckova 275 Zlin 76001 Czech Republic;

Tomas Bata Univ Zlin Univ Inst Ctr Polymer Syst Trida Tomase Bati 5678 Zlin 76001 Czech Republic|Tomas Bata Univ Zlin Fac Technol Vavreckova 275 Zlin 76001 Czech Republic;

Tomas Bata Univ Zlin Univ Inst Ctr Polymer Syst Trida Tomase Bati 5678 Zlin 76001 Czech Republic;

Tomas Bata Univ Zlin Univ Inst Ctr Polymer Syst Trida Tomase Bati 5678 Zlin 76001 Czech Republic|Tomas Bata Univ Zlin Fac Technol Vavreckova 275 Zlin 76001 Czech Republic;

Tomas Bata Univ Zlin Univ Inst Ctr Polymer Syst Trida Tomase Bati 5678 Zlin 76001 Czech Republic|Tomas Bata Univ Zlin Fac Technol Vavreckova 275 Zlin 76001 Czech Republic;

Jozef Stefan Inst Dept Surface Engn Jamova Cesta 39 Ljubljana 1000 Slovenia;

Jozef Stefan Inst Dept Surface Engn Jamova Cesta 39 Ljubljana 1000 Slovenia;

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正文语种 eng
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关键词
Chitosan; Vanillin; Crosslinking; Solvent casting; Drug-polymer solubility; Controlled drug release; Transdermal delivery;

机译：壳聚糖;香草醛;交联;溶剂铸造;药物 - 聚合物溶解度;受控药物释放;透皮递送;

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2. Synthesis and Characterization of Chitosan-Polyvinyl Alcohol Blended with Cloisite 30B for Controlled Release of the Anticancer Drug Curcumin [J] . Umesh Kumar Parida, Ashok Kumar Nayak, Birendra Kumar Binhani, Journal of biomaterials and nanobiotechnology. . 2011,第4期

机译：壳聚糖-聚乙烯醇与多氯联苯30B掺合物的抗癌药姜黄素的控制释放
3. Polyvinyl Alcohol–Pectin Cryogel Films for Controlled Release of Enrofloxacin [J] . Yanina. N. Martinez, Lucrecia. Piñuel, Guillermo. R. Castro, Applied Biochemistry and Biotechnology . 2012,第5期

机译：聚乙烯醇-果胶低温凝胶膜可控制恩诺沙星的释放
4. Preparation of Chitosan-Polyvinyl Alcohol Blends and Studies on Thermal and Mechanical Properties [C] . Agil Abraham, P.A.Soloman, V.O.Rejini International Conference on Emerging Trends in Engineering, Science and Technology . 2017

机译：壳聚糖 - 聚乙烯醇共混物的制备及热能和力学性能研究
5. Controlled drug release from porous co-continuous polymer blends [D] . Xiang, Zhenyu 2009

机译：从多孔共连续聚合物共混物中控制释放的药物
6. Diffusion and Controlled Release in Physically Crosslinked Poly (Vinyl Alcohol)/Iota-Carrageenan Hydrogel Blends [O] . Catalin Croitoru, Ionut Claudiu Roata, Alexandru Pascu, 2020

机译：物理交联聚（乙烯醇）/ IOTA-carrageenan水凝胶混合物中的扩散和控制释放
7. Synthesis and Characterization of Chitosan-Polyvinyl Alcohol Blended with Cloisite 30B for Controlled Release of the Anticancer Drug Curcumin [O] . Umesh Kumar Parida, Ashok Kumar Nayak, Birendra Kumar Binhani, 2011

机译：壳聚糖-聚乙烯醇与多氯联苯磺酸钠30B的共混和表征以控制释放姜黄素。

Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends

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