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首页> 外文期刊>Materials science & engineering >Tuning bio-aerogel properties for controlling theophylline delivery. Part 1: Pectin aerogels
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Tuning bio-aerogel properties for controlling theophylline delivery. Part 1: Pectin aerogels

机译：调整生物气凝胶属性，用于控制Theophylline交付。 第1部分：果胶气凝胶

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摘要

A comprehensive study of release kinetics of a hydrophilic drug from bio-aerogels based on pectin was performed. Pectin aerogels were made by polymer dissolution, gelation (in some cases this step was omitted), solvent exchange and drying with supercritical CO2. Theophylline was loaded and its release was studied in the simulated gastric fluid during 1 h followed by the release in the simulated intestinal fluid. Pectin concentration, initial solution pH and concentration of calcium were varied to tune the properties of aerogel. The kinetics of theophylline release was monitored and correlated with aerogel density, specific surface area, and aerogel swelling and erosion. Various kinetic models were tested to identify the main physical mechanisms governing the release.
机译：进行了基于果胶的生物气凝胶的亲水药物释放动力学综合研究。 通过聚合物溶解，凝胶化（在某些情况下省略了该步骤），溶剂交换和用超临界CO 2干燥的果胶气凝胶。 装载了茶碱，在1小时内在模拟胃液中在模拟胃液中进行了释放，然后在模拟肠液中释放。 果胶浓度，初始溶液pH和钙浓度变化以调整气凝胶的性质。 监测茶碱释放的动力学和与气凝胶密度，比表面积和气凝胶肿胀和侵蚀相关的动力学。 测试了各种动力学模型，以确定释放释放的主要物理机制。

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