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首页> 外文期刊>Materials science & engineering >Biomineralized synthesis of a smart 02-regenerating nanoreactor for highly efficient starvation/gas therapy
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Biomineralized synthesis of a smart 02-regenerating nanoreactor for highly efficient starvation/gas therapy

机译：用于高效饥饿/气体疗法的智能02再生纳米反应器的生物丙原化合成

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摘要

The emerging starvation therapy holds great promise in cancer treatment, however, its therapeutic effect is heavily reduced by intracellular hypoxia and high glutathione (GSH) conditions. To overcome these limitations, a new concept of starvation therapy pattern that employs biodegradable carriers with special selectivity and exhibits excellent anti-migration and therapy effect without using any invasive chemotherapy drugs was developed. A facile biomineralization method is first chosen to synthesize human serum albumin and folic acid modified MnO2 to guarantee active targeting, long-term stability and responsive degradation in tumor microenvironment. Designed degradation remarkably reduces GSH contents and hugely elevates intracellular O2 levels, both of which significantly improve the catalytic efficiency of GOX. Furthermore, the by-product of H2O2 is intelligently used to oxidize L-arginine and the generated NO results into effective gas therapy. More importantly, the first anti-migration case of starvation therapy has been reported in this work, and detailed molecular mechanism study uncovers that lysosome damage and changes of mitochondria membrane potential contribute to cell apoptosis. This work opens up new ideas to construct novel green yet noninvasive methods to treat cancer and inhibit migration by using degradable carriers and endogenous substances to minimize adverse effect.
机译：新出现的饥饿治疗在癌症治疗中具有很大的希望，然而，由于细胞内缺氧和高谷胱甘肽（GSH）条件，其治疗效果严重降低。为了克服这些限制，开发了一种新的饥饿治疗模式的概念，其使用具有特殊选择性的可生物降解的载体，并且在不使用任何侵入性化疗药物的情况下表现出优异的抗迁移和治疗效果。首先选择容易生物蛋白化方法以合成人血清白蛋白和叶酸修饰的MNO2，以保证肿瘤微环境中的活性靶向，长期稳定性和响应性降解。设计的降解显着降低了GSH含量，并大大提升了细胞内O2水平，这两种含量显着提高了GOX的催化效率。此外，H 2 O 2的副产物智能地用于氧化L-精氨酸，并且产生的未产生有效的气体治疗。更重要的是，在这项工作中报道了饥饿治疗的第一种抗迁移案例，详细的分子机制研究发现，裂解体损伤和线粒体膜潜能的变化有助于细胞凋亡。这项工作开辟了新的思想，以通过使用可降解的载体和内源性物质来构建新的绿色但无侵入性方法来治疗癌症并抑制迁移，以最大限度地减少不良影响。

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  • 来源
    《Materials science & engineering》 |2021年第7期|112132.1-112132.11|共11页
  • 作者

    Peng Jingyi; Gong Peiwei; Song Shaohua; Zhao Kai; Zheng Xiaofeng; Liu Jinfeng; Liu Zhe;

  • 作者单位

    Qufu Normal Univ Sch Chem & Chem Engn Key Lab Life Organ Anal Qufu 273165 Shandong Peoples R China;

    Qufu Normal Univ Sch Chem & Chem Engn Key Lab Life Organ Anal Qufu 273165 Shandong Peoples R China|Northwestern Polytech Univ Ctr Adv Lubricat & Seal Mat State Key Lab Solidificat Proc Xian 710072 Peoples R China;

    Qufu Normal Univ Sch Chem & Chem Engn Key Lab Life Organ Anal Qufu 273165 Shandong Peoples R China;

    Qufu Normal Univ Sch Chem & Chem Engn Key Lab Life Organ Anal Qufu 273165 Shandong Peoples R China;

    Qufu Normal Univ Sch Chem & Chem Engn Key Lab Life Organ Anal Qufu 273165 Shandong Peoples R China;

    Qufu Normal Univ Sch Chem & Chem Engn Key Lab Life Organ Anal Qufu 273165 Shandong Peoples R China;

    Qufu Normal Univ Sch Chem & Chem Engn Key Lab Life Organ Anal Qufu 273165 Shandong Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Drug delivery; Structure design; Biomimetic synthesis; Surface modification; Synergistic treatment;

    机译：药物递送;结构设计;仿生合成;表面改性;协同治疗;

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