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首页> 外文期刊>Materials science & engineering >Ultrabroad-spectrum, multidrug resistant bacteria-killing, and biocompatible quaternized chitin derivative for infected wound healing
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Ultrabroad-spectrum, multidrug resistant bacteria-killing, and biocompatible quaternized chitin derivative for infected wound healing

机译：超级光谱，多药抗菌杀伤，以及生物相容性季铵化甲壳素被感染伤口愈合的衍生物

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摘要

Wound infections have consistently been recognized as serious threats to human. The design of antimicrobial and biocompatible wound dressings for infected wounds is an area of constant research. Herein, we homogeneously synthesized an ultrabroad-spectrum antimicrobial and biocompatible quaternized chitin derivative (QC-4) in a high-efficiency and sustainable route using aqueous KOH/urea solution. Particularly, QC-4 displayed powerful multidrug resistant bacteria-killing activities even at a very low antimicrobial concentration range from 500 ng/ mL to 5 mu g/mL, including clinically prevalent multidrug-resistant Escherichia coli (MDR-E. coli), methicillin resistant Staphylococcus aureus (MRSA), multidrug-resistant Pseudomonas aeruginosa (MRPA), and multidrugresistant Acinetobacter baumannii (MDR-A. baumannii). With the aim to facilitate clinical translation, we validated the biocompatibility and safety of QC-4 both in vitro and in vivo, and further assessed the effects of QC-4 on infected wound healing in a porcine infectious full-thickness skin wound model. QC-4 demonstrated significant reduction of microbial aggregates and enhanced wound-healing effects by promoted re-epithelialization and collagen deposition, which were quite comparable to that of commercial Alginate-Ag dressing and absolutely superior to commercial Chitoclot Bandage dressing. Additionally, we provided clear evidences that QC-4 had a unique mechanism of action by attracting electrostatically to the negatively charged microbial surface, thus damaging the microbial cell wall and membrane. Findings of this work provided robust preclinical rationale for the future translational applications of QC-4 as a novel ultrabroad-spectrum and multidrug resistant bacteriakilling antimicrobial wound dressing for clinical wound management.
机译：伤口感染一直被认为是对人类的严重威胁。用于感染伤口的抗微生物和生物相容性伤口敷料的设计是持续研究领域。在此，我们使用KOH /脲溶液水溶液在高效和可持续的途径中均匀地合成超广频谱抗微生物和生物相容性型甲壳素衍生物（QC-4）。特别地，QC-4均匀显示出强大的多药抗菌杀灭活性，即使在500ng / ml至5μg/ ml的非常低的抗微生物浓度范围内，包括临床普遍的多药抗性大肠杆菌（MDR-E.COLI），甲氧西林抗金黄色葡萄球菌（MRSA），多药抗性假单胞菌铜绿假单胞菌（MRPA），以及多强毒剂acinetobacter Baumannii（MDR-A.Baumannii）。旨在促进临床翻译，我们验证了体外和体内QC-4的生物相容性和安全性，并进一步评估了QC-4对猪传染性全厚皮肤伤口模型中感染伤口愈合的影响。 QC-4通过促进再上皮细胞化和胶原沉积来表现出显着降低微生物聚集体和增强的伤口愈合效果，这与商业藻酸酯-AG敷料和绝对优于商业蛋白酶绷带敷料相当可比较。此外，我们提供了清晰的证据，即QC-4通过静电吸引到带负电的微生物表面具有独特的作用机制，从而损害微生物细胞壁和膜。这项工作的调查结果为QC-4的未来翻译应用提供了坚固的临床前理由，作为一种新颖的超广频和多药抗性抗菌抗菌伤口敷料，用于临床伤口管理。

著录项

  • 来源
    《Materials science & engineering》 |2021年第7期|112177.1-112177.13|共13页
  • 作者

    Xia Tian; Xie Fang; Bian Xiaoen; Chen Zuhan; Zhang Shichen; Fang Zehong; Ye Qifa; Cai Jie; Wang Yanfeng;

  • 作者单位

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Wuhan 430072 Peoples R China;

    Wuhan Univ Coll Chem & Mol Sci Hubei Engn Ctr Nat Polymers based Med Mat Wuhan 430072 Peoples R China;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Wuhan 430072 Peoples R China;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Wuhan 430072 Peoples R China;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Wuhan 430072 Peoples R China;

    Nanchang Univ Dept Gen Surg Jiangxi Prov Peoples Hosp Nanchang 330006 Jiangxi Peoples R China;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Wuhan 430072 Peoples R China;

    Wuhan Univ Coll Chem & Mol Sci Hubei Engn Ctr Nat Polymers based Med Mat Wuhan 430072 Peoples R China|Wuhan Univ Res Inst Shenzhen Shenzhen 518057 Peoples R China;

    Wuhan Univ Zhongnan Hosp Inst Hepatobiliary Dis Wuhan 430072 Peoples R China|Wuhan Univ Coll Chem & Mol Sci Hubei Engn Ctr Nat Polymers based Med Mat Wuhan 430072 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Antimicrobial activities; Antimicrobial mechanism; Biocompatibility; Infected wound healing; Multidrug resistant pathogens; Quaternized chitin derivative;

    机译：抗菌活性;抗微生物机制;生物相容性;感染伤口愈合;多药抗性病原体;季铵化壳酸衍生物;

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