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首页> 外文期刊>Materials science & engineering >Ag- and Sr-enriched nanofibrous titanium phosphate phases as potential antimicrobial cement and coating for a biomedical alloy
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Ag- and Sr-enriched nanofibrous titanium phosphate phases as potential antimicrobial cement and coating for a biomedical alloy

机译：Ag-和SR富含纳米纤维钛的磷酸阶段作为生物医学合金的潜在抗微生物水泥和涂层

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Biomaterials and their surfaces regulate the biological response and ultimately the quality of healing at a possible site of implantation. The physical, chemical and topographical properties of implants' surfaces play a decisive role in the biological integration process for their immediate loading and long-term success. Since at this level of biological interaction nano-dimensionality is basically entailed, bio-functional nanostructured composites either as filling/cement or coating to metallic implants are required. This study shows the possibility of synthesizing two phases of nanostructured titanium phosphate (pi and rho polymorphs) and enriching them with silver nanoparticles and strontium. More importantly, Ag-Sr-enriched nanostructured pi-titanium phosphate is induced to grow on a commercially available titanium alloy (Ti-6Al-4V), widely used in orthopedic and dental implants, under highly controlled conditions. Structural and microscopic studies, using XRD, HRTEM and SEM altogether confirm the resultant phases and their enrichment with strontium and silver nanoparticles with an average particle size around 6 nm. Using confocal laser scanning microscopy, the surface roughness was measured and is found to lay at the interface between the nanosized and microsized topologies. Ion release assessments showed that the presence of strontium controlled the release rate of silver ions and this could be beneficial in terms of decreasing the accompanied cytotoxicity that is usually encountered at high concentrations of silver release. Antimicrobial and cell proliferation assays have proved that enriching titanium phosphate with strontium and silver nanoparticles has improved their antimicrobial properties, while the cytotoxicity could be controlled.
机译：生物材料及其表面调节生物反应，最终在可能的植入部位愈合的质量。植入物表面的物理，化学和地形特性在生物整合过程中起着决定性作用，以便立即加载和长期成功。由于在这种生物相互作用纳米维度基本上需要，因此需要将生物官能纳米结构复合材料作为填充/水泥或涂层填充到金属植入物。该研究表明，合成纳米结构钛磷酸钛（PI和RHO多晶型物）两相的可能性，并用银纳米颗粒和锶富集它们。更重要的是，富含Ag-SR富含纳米结构的磷酸钛磷酸盐在可商购的钛合金（Ti-6Al-4V）上生长，广泛用于矫形和牙科植入物，在高度控制的条件下。使用XRD，HRTEM和SEM的结构和微观研究确认所得相的阶段和富集的锶和银纳米粒子，其平均粒度约为6nm。使用共聚焦激光扫描显微镜，测量表面粗糙度，并被发现铺设在纳米和微态拓扑之间的界面处。离子释放评估表明，锶的存在控制了银离子的释放速率，并且在减少在高浓度的银释放中遇到的伴随细胞毒性的术语可能是有益的。已经证明，抗微生物和细胞增殖测定法富集磷酸钛和银纳米粒子具有改善其抗微生物性质，而可以控制细胞毒性。

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