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首页> 外文期刊>Materials science & engineering >Construction of chitosan scaffolds with controllable microchannel for tissue engineering and regenerative medicine
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Construction of chitosan scaffolds with controllable microchannel for tissue engineering and regenerative medicine

机译：用于组织工程和再生医学的可控微通道的壳聚糖支架施工

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摘要

Microchannels are effective means of enabling the functional performance of tissue engineering scaffolds. Chitosan, a partial deacetylation derivative of chitin, exhibiting excellent biocompatibility, has been widely used in clinical practice. However, development of chitosan scaffolds with controllable microchannels architecture remains an engineering challenge. Here, we generated chitosan scaffolds with adjustable microchannel by combining a 3D printing microfiber templates-leaching method and a freeze-drying method. We can precisely control the arrangement, diameter and density of microchannel within chitosan scaffolds. Moreover, the integrated bilayer scaffolds with the desired structural parameters in each layer were fabricated and exhibited no delamination. The flow rate and volume of the simulated fluid can be modulated by diverse channels architecture. Additionally, the microchannel structure promoted cell survival, proliferation and distribution in vitro, and improved cell and tissue ingrowth and vascular formation in vivo. This study opens a new road for constructing chitosan scaffolds, and can further extend their application scope across tissue engineering and regenerative medicine.
机译：微通道是有效手段，可以实现组织工程支架的功能性能。壳聚糖，甲壳素的部分脱乙酰化衍生物，表现出优异的生物相容性，已广泛用于临床实践。然而，具有可控微通道建筑的壳聚糖脚手架的发展仍然是工程挑战。这里，通过组合3D打印微纤维模板浸出方法和冷冻干燥方法，我们通过可调节微通道产生壳聚糖支架。我们可以精确地控制壳聚糖支架内微通道的布置，直径和密度。此外，制造了各层中具有所需结构参数的集成双层支架，并未表现出分层。模拟流体的流速和体积可以通过各种通道架构进行调制。另外，微通道结构在体外促进了细胞存活，增殖和分布，以及体内改善的细胞和组织生长和血管形成。本研究开设了一条建造壳聚糖支架的新道路，并进一步延长组织工程和再生医学的应用范围。

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  • 来源
    《Materials science & engineering》 |2021年第7期|112178.1-112178.14|共14页
  • 作者

    Jiang Zhuyan; Zhang Kaihui; Du Lilong; Cheng Zhaojun; Zhang Tongxing; Ding Ji; Li Wen; Xu Baoshan; Zhu Meifeng;

  • 作者单位

    Tianjin Med Univ Hosp Tianjin Med Univ 2 Tianjin 300070 Peoples R China|Tianjin Med Univ Grad Sch Tianjin 300070 Peoples R China;

    Tianjin Med Univ Grad Sch Tianjin 300070 Peoples R China;

    Tianjin Hosp Dept Minimally Invas Spine Surg Tianjin 300211 Peoples R China;

    Tianjin Hosp Dept Minimally Invas Spine Surg Tianjin 300211 Peoples R China;

    Tianjin Hosp Dept Minimally Invas Spine Surg Tianjin 300211 Peoples R China;

    Tianjin Med Univ Grad Sch Tianjin 300070 Peoples R China|Tianjin Hosp Dept Minimally Invas Spine Surg Tianjin 300211 Peoples R China;

    Nankai Univ Coll Life Sci Key Lab Bioact Mat State Key Lab Med Chem Biol Minist Educ Tianjin 300071 Peoples R China;

    Tianjin Med Univ Grad Sch Tianjin 300070 Peoples R China|Tianjin Hosp Dept Minimally Invas Spine Surg Tianjin 300211 Peoples R China;

    Nankai Univ Coll Life Sci Key Lab Bioact Mat State Key Lab Med Chem Biol Minist Educ Tianjin 300071 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Chitosan scaffolds; Microchannel; Cell infiltration; 3D printing microfiber templates;

    机译：壳聚糖脚手架;微通道;细胞浸润;3D打印超细纤维模板;

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