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Surface engineered nanocarriers for the management of breast cancer

机译：表面工程纳米载波用于乳腺癌的管理

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Breast cancer is commonly known life-threatening malignancy in women after lung cancer. The standard of care (SOC) treatment for breast cancer primarily includes surgery, radiotherapy, hormonal therapy, and chemo-therapy. However, the effectiveness of conventional chemotherapy is restricted by several limitations such as poor targeting, drug resistance, poor drug delivery, and high toxicity. Nanoparticulate drug delivery systems have gained a lot of interest in the scientific community because of its unique features and promising potential in breast cancer diagnosis and treatment. The unique physicochemical and biological properties of the nano-particulate drug delivery systems promotes the drug accumulation, Pharmacokinetic profile towards the tumor site and thereby, reduces the cytotoxicity towards healthy cells. In addition, to improve tumor-specific drug delivery, researchers have focused on surface engineered nanocarrier system with targeting molecules/ligands that are specific to overexpressed receptors present on cancer cells. In this review, we have summarized the different biological ligands and surface-engineered nanoparticles, enlightening the physicochemical character-istics, toxic effects, and regulatory considerations of nanoparticles involved in treatment of breast cancer.
机译：乳腺癌是肺癌后妇女常规危及生命的恶性肿瘤。乳腺癌的护理标准（SOC）治疗主要包括手术，放疗，激素治疗和化疗治疗。然而，常规化疗的有效性受到若干局限性的限制，靶向差，耐药性，药物递送差和高毒性。由于其独特的特征和乳腺癌诊断和治疗潜力，纳米颗粒药物递送系统对科学界进行了很多兴趣。纳米颗粒药物递送系统的独特物理化学和生物学性质促进药代动力学曲线朝向肿瘤部位，从而降低了对健康细胞的细胞毒性。此外，为了改善肿瘤特异性药物递送，研究人员专注于表面工程纳米载体系统，其具有特异于癌细胞上存在的过表达受体的靶向分子/配体。在本文中，我们总结了不同的生物配体和表面设计的纳米颗粒，启示了纳米颗粒治疗乳腺癌的纳米颗粒的物理化学性质，毒性效应和调节性考虑。

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