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首页> 外文期刊>Materials science & engineering >Modulating nitric oxide-generating activity of zinc oxide by morphology control and surface modification
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Modulating nitric oxide-generating activity of zinc oxide by morphology control and surface modification

机译：通过形态控制和表面改性调节氧化锌的一氧化氮活性

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摘要

Zinc oxide (ZnO) has emerged as a promising material for nitric oxide (NO) delivery owing to its intrinsic enzyme-mimicking activities to catalyze NO prodrugs S-nitrosoglutathione (GSNO) and beta-gal-NONOate for NO generation. The catalytic performance of enzyme mimics is strongly dependent on their size, shape, and surface chemistry; however, no studies have evaluated the influence of the aforementioned factors on the NO-generating activity of ZnO. Understanding these factors will provide an opportunity to tune NO generation profiles to accommodate diverse biomedical applications. In this paper, for the first time, we demonstrate that the activity of ZnO towards catalytic NO generation is shape-dependent, resulting from the different crystal growth directions of these particles. We modified the surfaces of ZnO particles with zeolitic imidazolate framework (ZIF-8) by in situ synthesis and observed that ZnO/ZIF-8 retained 60% of its NO-generating potency. The newly formed ZnO/ZIF-8 particles were shown to catalytically decompose both endogenous (GSNO) and exogenous (beta-gal-NONOate and S-nitroso-N-acetylpenicillamine (SNAP)) prodrugs to generate NO at physiological conditions. In addition, we design the first platform that combines NO-generating and superoxide radical scavenging properties by encapsulating a natural enzyme, superoxidase dismutase (SOD), into ZnO/ZIF-8 particles, which holds great promise towards combinatorial therapy.
机译：由于其内在酶 - 模拟活性，氧化锌（ZnO）作为一氧化氮（NO）递送的有希望的材料，以催化未产生的前药S-NITROSOGLUTATHIONE（GSNO）和β-加仑非酸酯。酶模拟物的催化性能强烈取决于其尺寸，形状和表面化学;然而，没有研究过上述因素对ZnO的无生成活性的影响。了解这些因素将提供一个机会，无法调整多种生物医学应用程序。在本文中，我们首次证明ZnO对催化不代的活性依赖性，由这些颗粒的不同晶体生长方向产生。我们通过原位合成将ZnO颗粒的表面与沸石咪唑酯骨架（ZIF-8）进行了修饰，并观察到ZnO / ZIF-8保留了其无生成效力的60％。显示新形成的ZnO / ZIF-8颗粒以催化分解内源性（GSNO）和外源（β-加仑 - 非酸酯和S-硝基 - N-乙酰戊基（SNAP））前药，以在生理条件下产生否。此外，我们设计了通过将天然酶，超氧化酶歧化酶（SOD）包封在ZnO / ZIF-8颗粒中，将无生成和超氧化物自由基清除性能结合在ZnO / ZIF-8颗粒中。

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  • 来源
    《Materials science & engineering》 |2021年第11期|112428.1-112428.10|共10页
  • 作者

    Yang Tao; Zhou Yingzhu; Cheong Soshan; Kong Charlie; Mazur Federico; Liang Kang; Chandrawati Rona;

  • 作者单位

    UNSW Sydney Sch Chem Engn Sydney NSW 2052 Australia|UNSW Sydney ACN Sydney NSW 2052 Australia|Imperial Coll London Dept Mat London SW7 2AZ England;

    UNSW Sydney Sch Chem Engn Sydney NSW 2052 Australia|UNSW Sydney ACN Sydney NSW 2052 Australia;

    UNSW Sydney Mark Wainwright Analyt Ctr Elect Microscope Unit Sydney NSW 2052 Australia;

    UNSW Sydney Mark Wainwright Analyt Ctr Elect Microscope Unit Sydney NSW 2052 Australia;

    UNSW Sydney Sch Chem Engn Sydney NSW 2052 Australia|UNSW Sydney ACN Sydney NSW 2052 Australia;

    UNSW Sydney Sch Chem Engn Sydney NSW 2052 Australia|UNSW Sydney ACN Sydney NSW 2052 Australia|UNSW Sydney Grad Sch Biomed Engn Sydney NSW 2052 Australia;

    UNSW Sydney Sch Chem Engn Sydney NSW 2052 Australia|UNSW Sydney ACN Sydney NSW 2052 Australia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Nitric oxide; Zinc oxide; Enzyme mimics;

    机译：一氧化氮;氧化锌;酶模拟;

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