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首页> 外文期刊>Materials science & engineering >mSLA-based 3D printing of acrylated epoxidized soybean oil - nano-hydroxyapatite composites for bone repair
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mSLA-based 3D printing of acrylated epoxidized soybean oil - nano-hydroxyapatite composites for bone repair

机译：基于MSLA的丙烯酸环氧化豆油 - 纳米羟基磷灰石复合材料进行骨修复

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Structural bone allografts are used to treat critically sized segmental bone defects (CSBDs) as such defects are too large to heal naturally. Development of biomaterials with competent mechanical properties that can also facilitate new bone formation is a major challenge for CSBD repair. 3D printed synthetic bone grafts are a possible alternative to structural allografts if engineered to provide appropriate structure with sufficient mechanical properties. In this work, we fabricated a set of novel nanocomposite biomaterials consisting of acrylated epoxidized soybean oil (AESO), polyethylene glycol diacrylate (PEGDA) and nanohydroxyapatite (nHA) by using masked stereolithography (mSLA)-based 3D printing. The nanocomposite inks possess suitable rheological properties and good printability to print complex, anatomically-precise, 'by design' grafts. The addition of nHA to the AESO/PEGDA resin improved the tensile strength and fracture toughness of the mSLA printed nanocomposites, presumably due to small-scale reinforcement. By adding 10 vol% nHA, tensile strength, modulus and fracture toughness (KIc) were increased to 30.8 +/- 1.2 MPa (58% increase), 1984.4 +/- 126.7 MPa (144% increase) and 0.6 +/- 0.1 MPa.m1/2 (42% increase), respectively (relative to the pure resin). The nanocomposites did not demonstrate significant hydrolytic, enzymatic or oxidative degradation when incubated for 28 days, assuring chemical and mechanical stability at early stages of implantation. Apatite nucleated and covered the nanocomposite surfaces within 7 days of incubation in simulated body fluid. Good viability and proliferation of differentiated MC3T3-E1 osteoblasts were also observed on the nanocomposites. Taken all together, our nanocomposites demonstrate excellent bone-bioactivity and potential for bone defect repair.
机译：由于这些缺陷太大而无法自然地愈合，结构骨同种异体移植物用于治疗重症尺寸大小的节段性骨缺损（CSBD）。具有能干机械性能的生物材料的发展，也可以促进新的骨骼形成是CSBD修复的主要挑战。 3D印刷的合成骨移植物是结构同种异体移植物的可能替代方案，如果工程化，可提供具有足够的机械性能的适当结构。在这项工作中，我们通过使用掩蔽的立体化（MSLA）基于3D印刷，制造了一组由丙烯酸丙烯酸酯化的大豆油（AESO），聚乙二醇二烷基酯（PEGDA）和纳米羟基磷灰石（NHA）组成的新型纳米复合体生物材料。纳米复合材料墨水具有合适的流变性能和良好的印刷性，可通过设计的移植物印刷复合物，解剖学 - 精确，“。添加NHA至Aeso / PEGDA树脂改善了MSLA印刷纳米复合材料的拉伸强度和断裂韧性，可能是由于小规模增强。通过加入10体积％的NHA，拉伸强度，模量和断裂韧性（KIC）升至30.8 +/- 1.2MPa（增加58％），1984.4 +/- 126.7MPa（增加144％）和0.6 +/- 0.1MPa分别（相对于纯树脂）分别为.m1 / 2（增加42％）。当孵育28天时，纳米复合材料未显示出显着的水解，酶或氧化降解，确保植入早期的化学和机械稳定性。磷灰石在模拟体液孵育的培养后7天内含有纳米复合表面。在纳米复合材料上也观察到良好的可活力和分化的MC3-E1成骨细胞的增殖。我们一起服用，我们的纳米复合材料表现出优异的骨骼生物活性和骨缺损修复的潜力。

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