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首页> 外文期刊>Materials Science & Engineering >Low temperature additive manufacturing of three dimensional scaffolds for bone-tissue engineering applications: Processing related challenges and property assessment
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Low temperature additive manufacturing of three dimensional scaffolds for bone-tissue engineering applications: Processing related challenges and property assessment

机译：用于骨组织工程应用的三维支架的低温增材制造：与加工相关的挑战和性能评估

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摘要

In the last two decades, additive manufacturing (AM) has made significant progress towards the fabrication of biomaterials and tissue engineering constructs. One direction of research is focused on the development of mechanically stable implants with patient-specific size/shape and another direction has been to fabricate tissue-engineered scaffolds with designed porous architecture to facilitate vascularization. Among AM techniques, three dimensional powder printing (3DPP) is suitable for fabrication of bone related prosthetic devices, while three dimensional plotting (3DPL) is based on extrusion of biopolymers to create artificial tissues. In the present review, we aim to develop a better understanding of the science and engineering aspects of these low temperature AM techniques (3DPP and 3DPL) in the context of the bone-tissue engineering applications. While recognizing multiple property requirements of a 3D scaffold, the central theme is to discuss the critical roles played by the binder and powder properties together with the interplay among processing parameters in the context of the physics of binder-material interaction for the fabrication of implants with predefined architecture having structural complexity. An effort also has been exerted to discuss the existing challenges to translate the design concepts and material/binder formulations to develop implantable scaffolds with a more emphasis on bioceramics and biopolymers. Summarizing, this review highlights the need to adopt intelligent processing approaches and targeted application-specific biocompatibility characterization, while fabricating mechanically stable and biologically functionalized 3D tissue equivalents.
机译：在过去的二十年中，增材制造（AM）在制造生物材料和组织工程构造方面取得了重大进展。研究的一个方向集中在开发具有患者特定大小/形状的机械稳定植入物，而另一个方向是制造具有设计的多孔结构以促进血管形成的组织工程支架。在AM技术中，三维粉末印刷（3DPP）适用于制造与骨骼相关的修复设备，而三维绘图（3DPL）基于生物聚合物的挤出以创建人造组织。在本综述中，我们旨在在骨组织工程应用的背景下更好地理解这些低温增材制造技术（3DPP和3DPL）的科学和工程方面。在认识到3D支架的多种性能要求的同时，中心主题是讨论粘合剂和粉末性能在粘合剂与材料相互作用的物理学背景下用于制造植入物的关键作用，以及加工参数之间的相互作用。具有结构复杂性的预定义体系结构。还进行了努力来讨论将设计概念和材料/粘合剂配方转化为开发可植入支架的现存挑战，其中更着重于生物陶瓷和生物聚合物。总而言之，本综述强调了在制造机械稳定且具有生物学功能的3D组织等同物时，需要采用智能处理方法和针对特定应用的生物相容性表征。

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  • 来源
    《Materials Science & Engineering》 |2016年第5期|1-39|共39页
  • 作者

    Alok Kumar; Sourav Mandal; Srimanta Barui; Ramakrishna Vasireddi; Uwe Gbureck; Michael Gelinsky; Bikramjit Basu;

  • 作者单位

    Laboratory for Biomaterials and Translational Center on Biomaterials for Orthopedic and Dental Applications, Materials Research Centre, Indian Institute of Science, Bangalore, India;

    Laboratory for Biomaterials and Translational Center on Biomaterials for Orthopedic and Dental Applications, Materials Research Centre, Indian Institute of Science, Bangalore, India;

    Laboratory for Biomaterials and Translational Center on Biomaterials for Orthopedic and Dental Applications, Materials Research Centre, Indian Institute of Science, Bangalore, India;

    Laboratory for Biomaterials and Translational Center on Biomaterials for Orthopedic and Dental Applications, Materials Research Centre, Indian Institute of Science, Bangalore, India;

    Department for Functional Materials in Medicine and Dentistry, University Hospital of Wuerzburg, Wuerzburg, Germany;

    Centre for Translational Bone, Joint and Soft Tissue Research, Medical Faculty and University Hospital, Technische Universitaet Dresden, Dresden, Germany;

    Laboratory for Biomaterials and Translational Center on Biomaterials for Orthopedic and Dental Applications, Materials Research Centre, Indian Institute of Science, Bangalore, India;

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  • 关键词

    Rapid prototyping; Additive manufacturing; 3D powder printing; 3D plotting; Porous scaffold; Bone tissue regeneration;

    机译：快速原型制作;添加剂制造;3D粉末打印;3D绘图;多孔支架骨组织再生;

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