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Nanoparticles for improving cancer diagnosis

机译：纳米粒子可改善癌症诊断

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摘要

Despite the progress in developing new therapeutic modalities, cancer remains one of the leading diseases causing human mortality. This is mainly attributed to the inability to diagnose tumors in their early stage. By the time the tumor is confirmed, the cancer may have already metastasized, thereby making therapies challenging or even impossible. It is therefore crucial to develop new or to improve existing diagnostic tools to enable diagnosis of cancer in its early or even pre-syndrome stage. The emergence of nanotechnology has provided such a possibility. Unique physical and physiochemical properties allow nanoparticles to be utilized as tags with excellent sensitivity. When coupled with the appropriate targeting molecules, nanoparticle-based probes can interact with a biological system and sense biological changes on the molecular level with unprecedented accuracy. In the past several years, much progress has been made in applying nanotechnology to clinical imaging and diagnostics, and interdisciplinary efforts have made an impact on clinical cancer management. This article aims to review the progress in this exciting area with emphases on the preparation and engineering techniques that have been developed to assemble "smart" nanoprobes.
机译：尽管在开发新的治疗方法方面取得了进展，但是癌症仍然是导致人类死亡的主要疾病之一。这主要归因于无法在早期诊断肿瘤。到肿瘤被确认时，癌症可能已经转移，从而使疗法具有挑战性甚至是不可能的。因此，至关重要的是开发新的或改进现有的诊断工具，以使其能够在早期或什至综合征之前阶段进行癌症诊断。纳米技术的出现提供了这种可能性。独特的物理和物理化学特性使纳米颗粒可以用作具有出色灵敏度的标签。当与适当的靶向分子结合时，基于纳米颗粒的探针可以与生物系统相互作用，并以前所未有的准确性在分子水平上感知生物变化。在过去的几年中，在将纳米技术应用于临床影像和诊断方面已经取得了很大的进步，跨学科的努力对临床癌症的管理产生了影响。本文旨在回顾这一激动人心的领域的进展，重点是已开发出用于组装“智能”纳米探针的制备和工程技术。

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  • 来源
    《Materials Science & Engineering》 |2013年第3期|35-69|共35页
  • 作者

    Hongmin Chen; Zipeng Zhen; Trever Todd; Paul K. Chu; Jin Xie;

  • 作者单位

    Department of Chemistry and Bio-Imaging Research Center, University of Georgia, 1001Cedar Street, Athens, CA 30602, United States;

    Department of Chemistry and Bio-Imaging Research Center, University of Georgia, 1001Cedar Street, Athens, CA 30602, United States;

    Department of Chemistry and Bio-Imaging Research Center, University of Georgia, 1001Cedar Street, Athens, CA 30602, United States;

    Department of Physics & Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China;

    Department of Chemistry and Bio-Imaging Research Center, University of Georgia, 1001Cedar Street, Athens, CA 30602, United States;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    Cancer diagnosis; Biomarkers; Nanotechnology; Nanomedicine; Bio-conjugation; Surface modification Imaging;

    机译：癌症诊断;生物标志物;纳米技术;纳米医学生物共轭;表面改性成像;

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