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Medium chain length polyhydroxyalkanoates, promising new biomedical materials for the future

机译：中链长度的聚羟基链烷酸酯，有望为未来的新型生物医学材料

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摘要

Medium chain length polyhydroxyalkanoates, mcl-PHAs (C_6-C_14 carbon atoms), are polyesters of hydroxyalkanoates produced mainly by fluorescent Pseudomonads under unbalanced growth conditions. These mcl-PHAs which can be porduced,using renewable resources are biocompatible, biodegradable and thermoprocessable. They have low crystallinity, low glass transition temperature, low tensile strength and high elongation to break, making them elastomeric polymers. Mcl-PHAs and their copolymers are suitable for a range of biomedical applications where flexible biomaterials are required, such as heart valves and other cardiovascular applications as well as matrices for controlled drug delivery. Mcl-PHAs are more structurally diverse than short chain length PHAs and hence can be more readily tailored for specific applications. Composites have also been fabricated using mcl-PHAs and their copolymers, such as poly (3-hydroxyoctanoate) [P(3HO)] combined with single walled carbon nanotubes and poly(3-hydroxbutyrate-co-3-hydroxyhexanoate) (P(3HB-co-3HHx)] combined with hydroxyapatite. Because of these attractive properties of biodegradability, biocompatibility and tailorability, Mcl-PHAs and their composites are being increasingly used for biomedical applications. However, studies remain limited mainly to P(3HO) and the copolymer P(3HB-co-3HHx), which are the only mcl-PHAs available in large quantities. In this review we have consolidated current knowledge on the properties and biomedical applications of these elastomeric mcl-PHAs, their copolymers and their composites.
机译：中链长度的多羟基链烷酸酯，mcl-PHA（C_6-C_14碳原子）是主要由荧光假单胞菌在不平衡的生长条件下生产的羟基链烷酸酯的聚酯。可以使用可再生资源进行生产的这些mcl-PHA具有生物相容性，可生物降解性和可热加工性。它们具有低结晶度，低玻璃化转变温度，低拉伸强度和高断裂伸长率，使其成为弹性体聚合物。 Mcl-PHA及其共聚物适用于需要柔性生物材料的一系列生物医学应用，例如心脏瓣膜和其他心血管应用以及用于控制药物输送的基质。 Mcl-PHA在结构上比短链长度的PHA更多样化，因此可以更容易地针对特定应用进行定制。还已经使用mcl-PHAs及其共聚物制造了复合材料，例如与单壁碳纳米管结合的聚（3-羟基辛酸酯）[P（3HO）]和聚（3-羟基丁酸酯-co-3-羟基己酸酯）（P（3HB -co-3HHx）]与羟基磷灰石结合，由于这些具有生物降解性，生物相容性和适应性的诱人特性，Mcl-PHA及其复合材料正越来越多地用于生物医学应用，但研究仍主要限于P（3HO）及其共聚物P（3HB-co-3HHx）是唯一可大量使用的mcl-PHA，在此综述中，我们巩固了有关这些弹性mcl-PHA，其共聚物和复合材料的性能和生物医学应用的最新知识。

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  • 来源
    《Materials Science & Engineering》 |2011年第3期|p.29-47|共19页
  • 作者

    R. Rai; T. Keshavarz; J.A. Roether; A.R. Boccaccini; I. Roy;

  • 作者单位

    Department of Molecular and Applied Biosciences, School of Biosciences, University of Westminster, London, UK;

    Department of Molecular and Applied Biosciences, School of Biosciences, University of Westminster, London, UK;

    Department of Materials, Imperial College London, London SW7 2BP, UK,Institute for Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany;

    Department of Materials, Imperial College London, London SW7 2BP, UK,Institute for Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany;

    Department of Molecular and Applied Biosciences, School of Biosciences, University of Westminster, London, UK;

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  • 关键词

    polyhydroxyalkanoates biomedical applications polyesters poly(3-hydroxyoctanoate) tissue engineering composites;

    机译：聚羟基链烷酸酯生物医学应用聚酯聚（3-羟基辛酸酯）组织工程复合材料;

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