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首页> 外文期刊>Mathematical and Computer Modelling of Dynamical Systems >Effect of gravity on subject-specific human lung deformation
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Effect of gravity on subject-specific human lung deformation

机译：重力对受试者特定的人肺变形的影响

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摘要

A biomechanical model of human lung is developed and used to investigate the effect of gravity on lung deformation. The lung is assumed to behave as a poro-elastic medium with spatially dependent elastic property. Finite element analysis is performed on a three-dimensional (3D) lung geometry reconstructed from a four-dimensional Computed Tomography (4DCT) scan dataset of human patient. The spatially dependent Young's modulus (YM) values are estimated using inverse analysis from a linear elastic deformation model. The predicted deformation of selected landmarks is monitored with and without gravity, and compared with data obtained from 4DCT registration. The results show that gravity indeed significantly affects the magnitude and distribution of lung deformation with the maximum displacement enhanced by 54% in the direction of gravity, for the conditions investigated. In summary, the accuracy of predicted deformation is improved through incorporation of gravity in the biomechanical model of lung.
机译：建立了人肺的生物力学模型，并将其用于研究重力对肺变形的影响。假定肺表现为具有空间依赖性弹性特性的孔隙弹性介质。对从人类患者的二维计算机断层扫描（4DCT）扫描数据集重建的三维（3D）肺几何形状进行了有限元分析。使用线性弹性变形模型的逆分析来估计空间相关的杨氏模量（YM）值。使用和不使用重力监控选定地标的预测变形，并将其与从4DCT注册获得的数据进行比较。结果表明，在所研究的条件下，重力确实显着影响肺变形的大小和分布，最大位移沿重力方向增加了54％。总之，通过将重力纳入肺的生物力学模型中，可以提高预测变形的准确性。

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