Estimating the Relative Stiffness between a Hepatic Lesion and the Liver Parenchyma through Biomechanical Simulations of the Breathing Process

Martinez-Sanchis S.; Ruperez M. J.; Nadal E.; Pareja E.; Brugger S.; Borzacchiello D.; Lopez-Andujar R.; Monserrat C.

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Estimating the Relative Stiffness between a Hepatic Lesion and the Liver Parenchyma through Biomechanical Simulations of the Breathing Process

机译：通过呼吸过程的生物力学模拟估算肝脏病变与肝实质之间的相对刚度

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In this paper, a method to in vivo estimate the relative stiffness between a hepatic lesion and the liver parenchyma is presented. This method is based on the finite element simulation of the deformation that the liver undergoes during the breathing process. Boundary conditions are obtained through a registration algorithm known as Coherent Point Drift (CPD), which compares the liver form in two phases of the breathing process. Finally, the relative stiffness of the tumour with respect to the liver parenchyma is calculated by means of a Genetic Algorithm, which does a blind search of this parameter. The relative stiffness together with the clinical information of the patient can be used to establish the type of hepatic lesion. The developed methodology was first applied to a test case, i.e., to a control case where the parameters were known, in order to verify its validity. After that, the method was applied to two real cases and low errors were obtained.

机译：在本文中，提出了一种在体内估计肝病变与肝实质之间的相对刚度的方法。该方法基于肝脏在呼吸过程中变形的有限元模拟。边界条件通过称为“相干点漂移”（CPD）的配准算法获得，该算法对呼吸过程的两个阶段中的肝脏形态进行了比较。最后，通过遗传算法计算肿瘤相对于肝实质的相对刚度，该算法对该参数进行盲搜索。相对刚度以及患者的临床信息可用于确定肝病变的类型。首先将开发的方法应用于测试案例，即应用于参数已知的控制案例，以验证其有效性。之后，将该方法应用于两个实际案例，并获得了较低的误差。

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《Mathematical Problems in Engineering》 |2018年第14期|5317324.1-5317324.10|共10页
作者
Martinez-Sanchis S.; Ruperez M. J.; Nadal E.; Pareja E.; Brugger S.; Borzacchiello D.; Lopez-Andujar R.; Monserrat C.;
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Univ Politecn Valencia, Ctr Invest Ingn Mecan & Mat, Camino Vera S-N, E-46022 Valencia, Spain;

Univ Politecn Valencia, Ctr Invest Ingn Mecan & Mat, Camino Vera S-N, E-46022 Valencia, Spain;

Univ Politecn Valencia, Ctr Invest Ingn Mecan & Mat, Camino Vera S-N, E-46022 Valencia, Spain;

Hosp Univ Dr Peset Aleixandre Valencia, Serv Cirugia Gen, Av Gaspar Aguilar 90, Valencia 46017, Spain;

Hosp Univ & Politecn La Fe Valencia, Serv Radiodiagnost, Bulevar Sur S-N, Valencia 46026, Spain;

Cent Nantes, Equipe Mat Proc & Technol Composites, 1 Rue Noe, F-44321 Nantes 3, France;

Hosp Univ & Politecn La Fe Valencia, Unidad Cirugia Hepatobiliopancreat, Bulevar Sur S-N, Valencia 46026, Spain;

Univ Politecn Valencia, Dept Sistemas Informat & Computac, Camino Vera S-N, E-46022 Valencia, Spain;

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1. Estimating the Relative Stiffness between a Hepatic Lesion and the Liver Parenchyma through Biomechanical Simulations of the Breathing Process [J] . S. Martnez-Sanchis, M. J. Ruprez, E. Nadal, Mathematical Problems in Engineering: Theory, Methods and Applications . 2018,第3期

机译：通过呼吸过程的生物力学模拟估算肝病变与肝实质之间的相对刚度
2. Polycystic liver disease: Hepatic venous outflow obstruction lesions of the noncystic parenchyma have major consequences [J] . Barbier Louise, Ronot Maxime, Aussilhou Béatrice, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2018,第2期

机译：多囊肝病：非狭隘的休密障碍梗阻性障碍症具有重大后果
3. Contrast between hypervascularized liver lesions and hepatic parenchyma: Early dynamic PET versus contrast-enhanced CT [J] . FreesmeyerM., WinkensT., SchierzJ.-H. Annals of nuclear medicine . 2014,第7期

机译：高血管化肝脏病变与肝实质之间的对比：早期动态PET与对比增强CT
4. Comparison of contrast medium injection protocols in dynamic hepatic CT: simulation of lesion-to-liver contrast difference using pharmacokinetic compartment modeling [C] . Soo Jeong Kim, Seoul National Univ., Seoul, Conference on physiology and function from multidimensional images . 1999

机译：动态肝CT中造影剂注射方案的比较：使用药代动力学隔室模型模拟病变与肝脏的对比差异
5. Modeling liquid evaporation and using molecular dynamics simulation to estimate diffusion coefficients and relative solvent drying times. [D] . Choudhary, Rehan. 2017

机译：对液体蒸发进行建模，并使用分子动力学仿真来估计扩散系数和相对溶剂干燥时间。
6. Estimating numerical error in neural network simulations on Graphics Processing Units [O] . James P Turner, Thomas Nowotny 2015

机译：在图形处理单元上的神经网络仿真中估计数值误差
7. Aim: To investigate the value of ElastPQ measurement for differential diagnosis of benign and malignant focal liver lesions (FLLs) by using histologic results as a reference standard. Material and methods: A total of 154 patients were included. ElastPQ measurement was performed for each lesion in which the shear wave speed (SWS) was measured. The difference in SWS and SWS ratio of FLL to surrounding liver were evaluated, and the cut off value was investigated. Receiver operating characteristic (ROC) curve was plotted to evaluate the diagnostic performance. Histology as a gold standard was obtained by surgery in all patients. Results: A total of 154 lesions including 129 (83.7 ) malignant FLLs and 25 (16.3 ) benign ones were analysed. The SWS of malignant and benign FLLs was significantly different, 2.77±0.68 m/s and 1.57±0.55 m/s (p<0.05). The SWS ratio of each FLL to surrounding liver parenchyma was 2.23±0.49 for malignant and 1.14±0.36 for benign FLLs (p<0.05). The cut off value for differential diagnosis was 2.06 m/s for SWS and 1.67 for SWS ratio. Conclusions: ElastPQ measurement provides reliable quantitative stiffness information of FLLs and may be helpful in the differential diagnosis between malignant and benign FLLs. [O] . Yi Dong, Wen-Ping Wang, Yadan Xu, 2017

机译：目的：通过使用组织学结果作为参考标准，研究ELASTPQ测量对良性和恶性局灶性肝病变（FLLS）的鉴别诊断的价值。材料和方法：共有154名患者。对测量剪切波速度（SWS）的每个病变进行ELASTPQ测量。评估了FL1与周围肝脏的SWS和SWS比的差异，研究了切断值。接收器操作特征（ROC）曲线被绘制以评估诊断性能。组织学作为金标准通过患者的手术获得。结果：共有154例病变，包括129名（83.7％）恶性FLLS和25（16.3％）良性物质。 SWS的恶性和良性FLLS显着差异，2.77±0.68 m / s和1.57±0.55 m / s（p <0.05）。对于良性FLL的恶性为2.23±0.36，每个FL1与周围肝实质的SWS比为2.23±0.36（P <0.05）。差分诊断的切断值为SWS和SWS比率为2.06米/秒。结论：ELASTPQ测量提供了FLLS的可靠定量刚度信息，可能有助于恶性和良性FLL之间的差异诊断。

Estimating the Relative Stiffness between a Hepatic Lesion and the Liver Parenchyma through Biomechanical Simulations of the Breathing Process

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