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Histobiomechanical Remodeling of the Cervix during Pregnancy: Proposed Framework

机译：怀孕期间宫颈的组织生物力学重塑：拟议框架

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摘要

Pregnancy involves a gradual change in tissue consistency, where, as gestational age increases a drop in stiffness is noticeable. The extracellular matrix (ECM) of the cervix whose behavior is controlled by the collagen structure is reconfigured, due to hormonal and protein related factors that degraded it. There is an increase in cellular and water content. The collagen maintains a stable percentage, although the synthesis-solubility interaction causes a transformation in the network increasing its diameter and waviness, which destabilizes the mechanical integrity. Further understanding of the remodeling of the cervix becomes a key element in the progress against preterm birth. However, since the woman is in a very delicate state, the available information is scattered. The aim is to provide a framework where the variation of the histological properties is linked with the individual biomechanical evolution of the constituents; therefore a multiscale approach to the problem can be made. The results of different authors were reviewed to obtain values of each component depending on the gestational age, and then they were combined with the mechanical development of each variable obtained from the outputs of numerical simulations of another author. An additive function is proposed, in which the mechanical contribution of each constituent is added to a reference value established for a nonpregnant state. Results show how biochemistry models the mechanical behavior of the tissue through the histology and morphology of the ECM.
机译：怀孕涉及组织一致性的逐渐变化，其中随着胎龄的增加，刚度明显下降。子宫颈的细胞外基质（ECM）的行为受到胶原蛋白结构的控制，这是由于激素和蛋白质相关的因素将其降解而重新配置的。细胞和水含量增加。胶原蛋白保持稳定的百分比，尽管合成-溶解性相互作用会引起网络中的转变，从而增加其直径和波纹度，从而破坏机械完整性。对子宫颈重塑的进一步了解成为抵抗早产进展的关键因素。但是，由于该妇女处于非常脆弱的状态，因此可用信息分散。目的是提供一个框架，其中组织学特性的变化与成分的个体生物力学演变相关；因此，可以针对该问题采取多尺度方法。审查了不同作者的结果，以获取各个组件的值，具体取决于胎龄，然后将其与从另一位作者的数值模拟输出中获得的每个变量的机械发展结合起来。提出了加法函数，其中将每个成分的机械作用添加到为非怀孕状态建立的参考值。结果表明，生物化学如何通过ECM的组织学和形态学来模拟组织的机械行为。

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  • 来源
    《Mathematical Problems in Engineering》 |2019年第5期|5957432.1-5957432.11|共11页
  • 作者

    Torres Jorge; Faris Inas; Callejas Antonio;

  • 作者单位

    Univ Granada, Dept Struct Mech, E-18071 Granada, Spain;

    Univ Granada, Dept Struct Mech, E-18071 Granada, Spain|Biosanitary Res Inst, Granada 18016, Spain;

    Univ Granada, Dept Struct Mech, E-18071 Granada, Spain|Biosanitary Res Inst, Granada 18016, Spain;

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