A false single nucleotide polymorphism generated by gene duplication compromises meat traceability

Arianne Sanz; Laura Ordovas; Pilar Zaragoza; Albina Sanz; Ignacio de Bias; Clementina Rodellar

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A false single nucleotide polymorphism generated by gene duplication compromises meat traceability

机译：基因复制产生的假单核苷酸多态性损害了肉的可追溯性

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Controlling meat traceability using SNPs is an effective method of ensuring food safety. We have analyzed several SNPs to create a panel for bovine genetic identification and traceability studies. One of these was the transversion g.329C>T (Genbank accession no. AJ496781) on the cytochrome P450 17A1 gene, which has been included in previously published panels. Using minisequencing reactions, we have tested 701 samples belonging to eight Spanish cattle breeds. Surprisingly, an excess of heterozygotes was detected, implying an extreme departure from Hardy-Weinberg equilibrium (P<0.001). By alignment analysis and sequencing, we detected that the g.329C>T SNP is a false positive polymorphism, which allows us to explain the inflated heterozygotic value. We recommend that this ambiguous SNP, as well as other polymorphisms located in this region, should not be used in identification, traceability or disease association studies. Annotation of these false SNPs should improve association studies and avoid misinterpretations.

机译：使用SNP控制肉的可追溯性是确保食品安全的有效方法。我们已经分析了几种SNP，以建立一个牛遗传鉴定和可追溯性研究小组。其中之一是细胞色素P450 17A1基因的转化g.329C> T（Genbank登录号AJ496781），该基因已包含在先前发表的文章中。使用微测序反应，我们已经测试了八个西班牙牛品种的701个样品。出人意料的是，检测到过量的杂合子，这意味着与Hardy-Weinberg平衡极度偏离（P <0.001）。通过比对分析和测序，我们发现g.329C> T SNP是假阳性多态性，这使我们能够解释夸大的杂合子值。我们建议不要将此歧义SNP以及该区域中的其他多态性用于识别，可追溯性或疾病关联研究。对这些错误的SNP的注释应改善关联研究，并避免误解。

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来源
《Meat Science》 |2012年第3期|p.347-351|共5页
作者
Arianne Sanz; Laura Ordovas; Pilar Zaragoza; Albina Sanz; Ignacio de Bias; Clementina Rodellar;
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作者单位

Laboratorio de Genetica Bioquimica (LACENBIO), Facultad de Veterinaria, Universidad de Zaragoza, Spain;

Laboratorio de Genetica Bioquimica (LACENBIO), Facultad de Veterinaria, Universidad de Zaragoza, Spain;

Laboratorio de Genetica Bioquimica (LACENBIO), Facultad de Veterinaria, Universidad de Zaragoza, Spain;

Area de Production, Centro de Investigation y Tecnologia Agroalimentaria de Aragon, Spain;

Unidad de Patologia Infecciosa y Epidemiologia, Facultad de Veterinaria, Universidad de Zaragoza, Spain;

Laboratorio de Genetica Bioquimica (LACENBIO), Facultad de Veterinaria, Universidad de Zaragoza, Spain;

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收录信息美国《科学引文索引》(SCI);
原文格式 PDF
正文语种 eng
中图分类
关键词
ANP; meat traceability; genetic identification; false SNP; duplication gene; excess of heterozygote;

机译：ANP;肉可追溯性;基因鉴定SNP错误;复制基因过量的杂合子;

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A false single nucleotide polymorphism generated by gene duplication compromises meat traceability

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