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Cultured meat from stem cells: Challenges and prospects

机译：干细胞培养肉：挑战与前景

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摘要

As one of the alternatives for livestock meat production, in vitro culturing of meat is currently studied. The generation of bio-artificial muscles from satellite cells has been ongoing for about 15 years, but has never been used for generation of meat, while it already is a great source of animal protein. In order to serve as a credible alternative to livestock meat, lab or factory grown meat should be efficiently produced and should mimic meat in all of its physical sensations, such as visual appearance, smell, texture and of course, taste. This is a formidable challenge even though all the technologies to create skeletal muscle and fat tissue have been developed and tested. The efficient culture of meat will primarily depend on culture conditions such as the source of medium and its composition. Protein synthesis by cultured skeletal muscle cells should further be maximized by finding the optimal combination of biochemical and physical conditions for the cells. Many of these variables are known, but their interactions are numerous and need to be mapped. This involves a systematic, if not systems, approach. Given the urgency of the problems that the meat industry is facing, this endeavor is worth undertaking. As an additional benefit, culturing meat may provide opportunities for production of novel and healthier products.
机译：作为家畜肉生产的替代方法之一，目前正在研究肉的体外培养。从卫星细胞产生生物人工肌肉已经进行了约15年，但从未用于产生肉，尽管它已经是动物蛋白质的重要​​来源。为了替代牲畜肉，可以有效地生产实验室或工厂生产的肉，并应在肉的所有物理感觉（例如视觉外观，气味，质地，当然还有味道）中模仿肉。即使开发和测试了用于创建骨骼肌和脂肪组织的所有技术，这也是一个艰巨的挑战。肉的有效培养将主要取决于培养条件，例如培养基的来源及其组成。通过寻找细胞生化和物理条件的最佳组合，应该进一步最大化培养的骨骼肌细胞的蛋白质合成。这些变量中有许多是已知的，但是它们之间的相互作用却很多，需要进行映射。这涉及一种系统的方法，如果不是系统的话。鉴于肉类行业所面临问题的紧迫性，这一努力值得进行。作为一项额外的好处，养殖肉类可能会提供生产新型健康产品的机会。

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  • 来源
    《Meat Science》 |2012年第3期|p.297-301|共5页
  • 作者

    Mark J. Post;

  • 作者单位

    Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM),Maastricht University, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    cell culture; tissue engineering; meat substitutes;

    机译：细胞培养;组织工程;肉替代品;

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