• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>IEEE / ASME Transactions on Mechatronics >Optimal Design and Implementation of a Novel Two-Dimensional Electromagnetic Navigation System That Allows Focused Heating of Magnetic Nanoparticles
【24h】

Optimal Design and Implementation of a Novel Two-Dimensional Electromagnetic Navigation System That Allows Focused Heating of Magnetic Nanoparticles

机译：新型二维电磁导航系统的最佳设计与实现，允许磁性纳米粒子的聚焦加热

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A magnetic drug-targeting system featuring real-time imaging, guidance, and local heating is required for more precise drug targeting and minimization of side effects. In this article, we present a novel electromagnetic navigation and heating system that not only guides and navigates magnetic nanoparticles (MNPs) with real-time imaging feedback, but also uses focused MNP heating to release drugs while monitoring the temperature. The magnetic field amplitude and magnetic gradient play key roles in our integrated system; we enhanced the gradient and field within a field of view of 30 x 30 mm. Performance was examined via simulation employing COMSOL Multiphysics software and verified experimentally. After optimization, the maximum gradients attained on the x and y axes are 4.15 and 2.23 T/m/mu(0), respectively, for the electromagnetic actuator mode, and 8.48 T/m/mu(0) for the magnetic particle imaging mode. The magnetic field amplitude for heating was 19.70 mT at 100 kHz. We then built a two-dimensional MNPs navigation/heating system to demonstrate the in vitro feasibility of our scheme; this afforded a 1-Hz navigation update rate during MNPs guidance in a Y-shaped channel and locally heated MNPs with temperature monitoring.
机译：需要具有实时成像，引导和局部加热的磁性药物靶向系统，以获得更精确的药物靶向和最小化副作用。在本文中，我们提出了一种新型电磁导航和加热系统，其不仅是通过实时成像反馈引导和导航和导航的磁性纳米颗粒（MNP），而且还使用聚焦的MNP加热来释放药物，同时监测温度。磁场幅度和磁梯度在我们的集成系统中扮演关键角色;我们在30 x 30 mm的视野中增强了梯度和字段。通过采用COMSOL Multiphysics软件的模拟检查性能并通过实验验证。优化后，x和y轴上所达到的最大梯度分别为4.15和2.23 t / m / mu（0），用于电磁致动器模式，8.48吨/ m / mu（0）用于磁粒子成像模式。加热的磁场幅度为19.70mt，100kHz。然后，我们建立了二维MNP导航/加热系统，以展示我们方案的体外可行性;这在Y形通道的MNP指导下提供了1 Hz导航更新速率，以及具有温度监测的本地加热MNP。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号