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首页> 外文期刊>Medical Molecular Morphology >Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progression
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Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progression

机译：E-钙粘着蛋白阻遏物，Snail，Slug，SIP1和Twist的表达在卵巢癌的发生和发展中的变化：Snail在卵巢肿瘤发生和发展中的重要作用

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摘要

Changes in the expression of E-cadherin have been reported to be important in the tumorigenesis and progression of epithelial ovarian carcinoma. To further examine the mechanisms regulating E-cadherin expression in ovarian tumorigenesis, we investigated the immunohis-tochemical expression of transcriptional repressors for E-cadherin, such as Snail, Slug, SIP1, and Twist, in the ovarian surface epithelium (OSE) and 95 cases of epithelial ovarian tumors. OSE cells were negative for SIP1 and Slug, whereas weak expression of Snail and Twist was observed in 8 (73%) and 3 (27%) cases, respectively. Of 95 ovarian tumors, the expression of Snail, Slug, S1P1, and Twist increased step-wise in benign, borderline, and malignant tumors. Among them, the expression of Snail showed significantly inverse correlation with that of E-cadherin. Regarding the FIGO stage classification, the expressions of Snail and Twist were significantly increased in advanced cases. The prognosis of ovarian carcinoma patients positive for Snail expression was poorer than that of negative patients. Our results indicate that the expression of E-cadherin transcriptional repressors increased with malignancy in ovarian epithelial neoplasms and that the expression of E-cadherin and its negative regulators is altered during ovarian cancer development and peritoneal dissemination.
机译：据报道，E-钙粘着蛋白表达的变化在上皮性卵巢癌的发生和发展中很重要。为了进一步检查在卵巢肿瘤发生中调节E-钙粘蛋白表达的机制，我们研究了卵巢表面上皮（OSE）和95中E-钙粘蛋白的转录阻遏物（例如Snail，Slug，SIP1和Twist）的免疫组织化学表达卵巢上皮肿瘤病例。 OSE细胞对SIP1和Slug呈阴性，而分别在8（73％）和3（27％）病例中观察到Snail和Twist的弱表达。在95个卵巢肿瘤中，在良性，交界性和恶性肿瘤中，Snail，Slug，S1P1和Twist的表达逐步增加。其中，Snail的表达与E-cadherin的表达呈显着的负相关。关于FIGO阶段分类，在晚期病例中Snail和Twist的表达明显增加。 Snail表达阳性的卵巢癌患者的预后要差于阴性患者。我们的结果表明，在卵巢上皮性肿瘤中，E-cadherin转录阻遏物的表达随恶性程度的增加而增加，并且在卵巢癌的发展和腹膜扩散过程中，E-cadherin及其负调控因子的表达也发生了改变。

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  • 来源
    《Medical Molecular Morphology》 |2009年第2期|82-91|共10页
  • 作者

    Junko Yoshida; Akiko Horiuchi; Norihiko Kikuchi; Akiko Hayashi; Ryosuke Osada; Satoshi Ohira; Tanri Shiozawa; Ikuo Konishi;

  • 作者单位

    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan;

    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan;

    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan;

    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan;

    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan;

    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan;

    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan;

    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan;

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  • 正文语种 eng
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  • 关键词

    snail; ovarian carcinoma; E-cadherin repressors; slug; twist;

    机译：蜗牛;卵巢癌E-钙粘蛋白阻遏物;ug捻;

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