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Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature

机译：常压高氧会增加急性缺血性卒中的氧化应激吗？对文学的批判性评论

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摘要

Stroke, one of the most debilitating cerebrovascular and nuerological diseases, is a serious life-threatening condition and a leading cause of long-term adult disability and brain damage, either directly or by secondary complications. Most effective treatments for stroke are time dependent such as the only FDA-approved therapy, reperfusion with tissue-type plasminogen activator; thus, improving tissue oxygenation with normobaric hyperoxia (NBO) has been considered a logical and potential important therapy. NBO is considered a good approach because of its potential clinical advantages, and many studies suggest that NBO is neuroprotective, reducing ischemic brain injury and infarct volume in addition to improving pathologic and neurobehavorial outcomes. However, increased reactive oxygen species (ROS) generation may occur when tissue oxygen level is too high or too low. Therefore, a major concern with NBO therapy in acute ischemic stroke is the potential increase of ROS, which could exacerbate brain injury. The purpose of this review is to critically review the current literature reports on the effect of NBO treatment on ROS and oxidative stress with respect to acute ischemic stroke. Considering the available data from relevant animal models, NBO does not increase ROS or oxidative stress if applied for a short duration; therefore, the potential that NBO is a viable neuroprotective strategy for acute ischemic stroke is compelling. The benefits of NBO may significantly outweigh the risks of potential increase in ROS generation for the treatment of acute ischemic stroke.
机译：中风是最令人衰弱的脑血管和神经病学疾病之一，是严重的威胁生命的状况，并且是直接或通过继发性并发症导致成人长期残疾和脑部损伤的主要原因。中风最有效的治疗方法是时间依赖性的，例如唯一的FDA批准的治疗方法，组织型纤溶酶原激活剂的再灌注。因此，利用常压高氧（NBO）改善组织氧合被认为是一种合理且潜在的重要疗法。 NBO由于其潜在的临床优势而被认为是一种很好的方法，许多研究表明NBO具有神经保护作用，除了改善病理和神经行为结局外，还可以减少缺血性脑损伤和梗塞体积。但是，当组织氧水平过高或过低时，可能会产生更多的活性氧（ROS）。因此，在急性缺血性卒中中，NBO治疗的一个主要问题是ROS的潜在增加，这可能加剧脑损伤。这篇综述的目的是严格地回顾一下有关急性缺血性卒中的NBO治疗对ROS和氧化应激的影响的现有文献报道。考虑到相关动物模型的可用数据，NBO短期施用不会增加ROS或氧化应激。因此，NBO是急性缺血性卒中可行的神经保护策略的潜力令人信服。 NBO的益处可能大大超过了治疗急性缺血性中风后ROS潜在增加的风险。

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