A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis

Eduardo Ekundi-Valentim; Filiphe PN Mesquita; Karen T Santos; Marco A Vieira de Paula; Juliana Florenzano; Cristiane I Zanoni; Leandro Rodrigues; Gilberto de Nucci; Simone A Teixeira; Heloisa HA Ferreira; John L Wallace; Soraia KP Costa; Marcelo N Muscará

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A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis

机译：单次口服萘普生及其释放硫化氢（H2S）衍生物ATB-346对角叉菜胶致滑膜炎大鼠抗炎作用的比较研究

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Background Non-steroidal antiinflammatory drugs (NSAIDs) are the most commonly prescribed agents for arthritic patients, although gastric effects limit their long-term use. Considering the reported gastric safety of hydrogen sulfide (H2S)-releasing NSAIDs, in addition to the anti-inflammatory effects of H2S administration to rats with synovitis, we decided to evaluate the effects of the H2S-releasing naproxen derivative ATB-346 in this animal model.

机译：背景技术非甾体类抗炎药（NSAIDs）是关节炎患者最常用的处方药，尽管胃病会限制其长期使用。考虑到已报道的释放硫化氢（H2S）的NSAID的胃安全性，除了H2S给药对滑膜炎大鼠的抗炎作用外，我们决定评估释放H2S的萘普生衍生物ATB-346在该动物中的作用模型。

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《Medical Gas Research》 |2013年第1期|1-9|共9页
作者
Eduardo Ekundi-Valentim; Filiphe PN Mesquita; Karen T Santos; Marco A Vieira de Paula; Juliana Florenzano; Cristiane I Zanoni; Leandro Rodrigues; Gilberto de Nucci; Simone A Teixeira; Heloisa HA Ferreira; John L Wallace; Soraia KP Costa; Marcelo N Muscará;
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正文语种 eng
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关键词
Hydrogen sulfide; NSAID; ATB-346; Synovitis; Joint; Inflammation; Rat;

机译：硫化氢;NSAID;ATB-346;滑膜炎;联合;炎;鼠;

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1. A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis [J] . Eduardo Ekundi-Valentim, Filiphe PN Mesquita, Karen T Santos, Medical Gas Research . 2013,第1期

机译：单次口服萘普生及其释放硫化氢（H2S）衍生物ATB-346对角叉菜胶致滑膜炎大鼠抗炎作用的比较研究
2. Influence of the slow-release H2S donor GYY4137 and the H2S-releasing naproxen derivative ATB-346 on postoperative ileus [J] . van Dingenen J., Lefebvre R. A. Neurogastroenterology and motility . 2018,第S1期

机译：缓释H2S供体Gyy4137的影响和H2S释放萘普生衍生物ATB-346在术后Ileus
3. THE EFFECT OF HYDROGEN SULFIDE-RELEASING NAPROXEN (ATB-346) VERSUS NAPROXEN ON FORMATION OF STRESS-INDUCED GASTRIC LESIONS, THE REGULATION OF SYSTEMIC INFLAMMATION, HYPOXIA AND ALTERATIONS IN GASTRIC MICROCIRCULATION [J] . M. MAGIEROWSKI, K. MAGIEROWSKA, M. SURMIAK, Journal of physiology and pharmacology: an official journal of the Polish Physiological Society . 2017,第5期

机译：释放硫化氢的萘普生（ATB-346）对萘普生对应激诱导的胃部病变形成，全身炎症，缺氧的调节以及胃微循环改变的影响
4. Study of Dispersing Hydrogen Sulfide (H2S) Generated from a Chemical Industry [C] . Olimpio Gomes da Silva Neto, Christian Alberto Lopes Burrone de Freitas Italian Association of Chemical Engineering;International Conference on Environmental Odour Monitoring and Control . 2016

机译：化学工业产生的分散硫化氢（H2S）的研究
5. The effects of hydrogen sulfide (H2S) on the release of inflammatory mediators from mouse macrophages. [D] . Huang, Caleb Weihao. 2017

机译：硫化氢（H2S）对从小鼠巨噬细胞释放炎性介质的影响。
6. A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis [O] . Eduardo Ekundi-Valentim, Filiphe PN Mesquita, Karen T Santos, 2013

机译：单次口服萘普生及其释放硫化氢（H2S）衍生物ATB-346对角叉菜胶致滑膜炎大鼠抗炎作用的比较研究
7. A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis [O] . Ekundi-Valentim, Eduardo, Mesquita, Filiphe P, Santos, Karen T, 2015

机译：单次口服萘普生及其释放硫化氢（H2S）衍生物ATB-346对角叉菜胶致滑膜炎大鼠抗炎作用的比较研究

A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis

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