Hypercapnia: is it protective in lung injury?

Alexander F Bautista; Ozan Akca

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Hypercapnia: is it protective in lung injury?

机译：高碳酸血症：对肺损伤有保护作用吗？

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Hypercapnic acidosis has been regarded as a tolerated side effect of protective lung ventilation strategies. Various in vivo and ex vivo animal studies have shown beneficial effects in acute lung injury setting, but some recent work raised concerns about its anti-inflammatory properties. This mini-review article aims to expand the potential clinical spectrum of hypercapnic acidosis in critically ill patients with lung injury. Despite the proven benefits of hypercapnic acidosis, further safety studies including dose-effect, level-and-onset of anti-inflammatory effect, and safe applicability period need to be performed in various models of lung injury in animals and humans to further elucidate its protective role.

机译：高碳酸血症性酸中毒被认为是肺保护性通气策略的耐受性副作用。各种体内和离体动物研究已显示出在急性肺损伤环境中的有益作用，但最近的一些工作引起了人们对其抗炎特性的关注。这篇小型综述文章旨在扩大重症肺损伤患者高碳酸血症性酸中毒的潜在临床范围。尽管高碳酸血症性酸中毒具有公认的益处，但仍需要在动物和人类的各种肺损伤模型中进行包括剂量效应，抗炎作用的水平和发作以及安全适用期在内的进一步安全性研究，以进一步阐明其保护作用角色。

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《Medical Gas Research》 |2013年第1期|1-5|共5页
作者
Alexander F Bautista; Ozan Akca;
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正文语种 eng
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Hypercapnia; Hypercarbia; Carbon Dioxide; Oxygenation; Acute Lung Injury (ALI); Ventilator Associated Lung Injury (VALI); Pneumonia; Sepsis; Acute Respiratory Distress Syndrome (ARDS); Ventilator-induced diaphragmatic dysfunction (VIDD);

机译：高碳酸血症;高碳酸血症;二氧化碳;氧合;急性肺损伤（ALI）;呼吸机相关肺损伤（VALI）;肺炎;败血症;急性呼吸窘迫综合征（ARDS）;呼吸机诱发的diaphragm肌功能障碍（VIDD）;

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1. alpha-Tocopherol transfer protein mediates protective hypercapnia in murine ventilator-induced lung injury [J] . Otulakowski Gail, Engelberts Doreen, Arima Hajime, Thorax: The Journal of the British Thoracic Society . 2017,第6期

机译：α-生育酚转移蛋白在小鼠呼吸机诱导的肺损伤中介导防护性血红蛋白
2. The protective effect of hypercapnia on ischemia-reperfusion injury in lungs [J] . Mrazkova Hana, Lischke Robert, Hodyc Daniel, Respiratory physiology & neurobiology . 2015,第Null期

机译：高碳酸血症对肺缺血再灌注损伤的保护作用
3. Hypercapnia: is it protective in lung injury? [J] . Alexander F Bautista, Ozan Akca Medical Gas Research . 2013,第1期

机译：高碳酸血症：对肺损伤有保护作用吗？
4. Protective Effect of Ginsenoside Rb1 Mixing with Several Lung Flush Solutions on Pulmonary Ischemia-Reperfusion Injury [C] . Fengwu Lin, Chuan Zhang, Qiang Zhang International Conference on Biotechnology, Chemical and Materials Engineering . 2014

机译：人参皂苷RB1与几种肺冲洗溶液对肺缺血再灌注损伤的保护作用
5. The protective role of surfactant protein A in oxidative and CP9-induced lung injury. [D] . Wang, Tie. 2005

机译：表面活性剂蛋白A在氧化和CP9诱导的肺损伤中的保护作用。
6. Hypercapnia: is it protective in lung injury? [O] . Alexander F Bautista, Ozan Akca 2013

机译：高碳酸血症：对肺损伤有保护作用吗？
7. Hypercapnia: is it protective in lung injury? [O] . 2013

机译：高碳酸血症：对肺损伤有保护作用吗？

Hypercapnia: is it protective in lung injury?

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