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首页> 外文期刊>Medical Gas Research >Hydrogen-rich saline ameliorates the retina against light-induced damage in rats
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Hydrogen-rich saline ameliorates the retina against light-induced damage in rats

机译：富含氢的盐水可改善视网膜，防止光损伤

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摘要

Oxidative reactions are thought to be a major cause of light-induced retinal degeneration. This study was designed to investigate the effects of hydrogen-rich saline (HRS) on the prevention and treatment of light-induced retinal injury in rats. Male Sprague–Dawley rats were divided randomly into three groups: light damage, HRS prevention (5ml/kg, 30min before intensive light exposure), and HRS treatment (5ml/kg per day for 5days, after intensive light exposure), respectively. The right eye of each rat was exposed to 5000 lux constant white light-emitting diode (LED) light for 3h, and the left eye was covered to serve as the blank control. Electroretinograms were recorded 5days later, and the thickness of the outer nuclear layer (ONL) was measured after hematoxylin and eosin (H&E) staining. The results showed that the electroretinogram b-wave amplitudes and the mean ONL thicknesses of rats were significantly greater in the HRS prevention (P < 0.001) and treatment (P < 0.001) groups than in the light damage. These results indicated that peritoneal injection of HRS provides protection and treatment against light-induced retinal degeneration in rats.
机译：氧化反应被认为是光诱导的视网膜变性的主要原因。这项研究旨在研究富氢盐水（HRS）在预防和治疗光诱发的大鼠视网膜损伤中的作用。将雄性Sprague–Dawley大鼠随机分为三组：光损伤，预防HRS（5ml / kg，在强光照射前30分钟）和HRS治疗（在强光照射后每天5ml / kg，连续5天，每天）。将每只大鼠的右眼暴露于5000 lux恒定白色发光二极管（LED）光线下3h，并遮盖左眼作为空白对照。 5天后记录视网膜电图，并在苏木精和曙红（H＆E）染色后测量外核层（ONL）的厚度。结果表明，在HRS预防组（P <0.001）和治疗组（P <0.001），视网膜电图b波振幅和平均ONL厚度明显大于光损伤组。这些结果表明，腹膜内注射HRS提供了针对光诱导的大鼠视网膜变性的保护和治疗。

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