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Does hyperbaric oxygen therapy have the potential to improve salivary gland function in irradiated head and neck cancer patients?

机译：高压氧疗法是否有可能改善辐照过的头颈癌患者的唾液腺功能？

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Following radiotherapy, many patients with osteoradionecrosis suffer from xerostomia, thereby decreasing their quality of life. Patients can develop problems with speech, eating, increased dental caries, dysphagia, fractured dentition, chronic refractory osteomyelitis and osteoradionecrosis. Symptoms associated with salivary gland dysfunction can be severe enough that patients terminate the course of their radiotherapy prematurely due to the decrease in their quality of life. Currently, the only treatments available to patients are palliative. A definitive treatment has yet to be discovered. Head and neck cancers, which comprise 5% of overall cancer treatments, rank 8th most expensive to treat in the United States today. Hyperbaric oxygen is being considered for the therapy of radiated salivary glands because it has been shown to stimulate capillary angiogenesis and fibroplasia in radiation treated tissues. It has been hypothesized that salivary acinar cells undergo apoptosis following radiation therapy. The purpose of this paper is to discuss the mechanisms of salivary gland injury and evaluate whether hyperbaric oxygen therapy improves salivary gland function in patients who develop xerostomia and osteoradionecrosis following head and neck radiation.
机译：放疗后，许多骨坏死患者患有口干症，从而降低了生活质量。患者会出现言语，进食，龋齿增加，吞咽困难，牙列断裂，慢性难治性骨髓炎和骨放射性坏死等问题。与唾液腺功能障碍有关的症状可能非常严重，以致患者由于生活质量下降而提前终止其放射治疗过程。当前，患者可用的唯一疗法是姑息疗法。确切的治疗方法尚未发现。头颈癌占整体癌症治疗的5％，在当今美国，头颈癌的治疗费用排名第8位。高压氧正被考虑用于放射唾液腺的治疗，因为已显示出高压氧可刺激放射治疗组织中的毛细血管新生和纤维化。假设唾液腺泡细胞在放射治疗后发生凋亡。本文的目的是探讨唾液腺损伤的机制，并评估高压氧治疗是否能改善头颈部放射后发生口干症和骨放射性坏死的患者唾液腺功能。

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