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首页> 外文期刊>Metabolomics >Estimation value of plasma amino acid target analysis to the acute radiation injury early triage in the rat model
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Estimation value of plasma amino acid target analysis to the acute radiation injury early triage in the rat model

机译：血浆氨基酸靶标分析对大鼠急性放射损伤早期分类的评估价值

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摘要

Rapid radiation injury early triage for large-scale people after radiation exposure is vital for limited medical resources allocation and early treatment of a large number of wounded after a nuclear accident. Owing to the high-throughput analysis and minimally invasive of collection sample, radiation metabolomics has been recently applied to radiation damage researches. Here, exploration the feasibility of estimating the acute radiation injury early triage by means of plasma amino acid target analysis was attempted using high performance liquid chromatography–electrospray tandem mass spectrometry (HPLC–ESI–MS/MS) technique. The nonlinear kernel partial least squares (KPLS) model was used to classify the radiation damage levels. The classification accuracy of without radiation exposure was 92.3 % at 5 h after exposure. At 24 h after exposure, the triage accuracies were all above 83 % in the different doses of irradiated groups, the correct classification rates of moderate and severe radiation injury were 91.7 and 92.3 % respectively. At 72 h after exposure, the classification accuracies of all levels of radiation injury were more than 90 %, the correct classification rates of moderate and severe groups were up to 100 %. This approach is useful for early predicting different levels of radiation exposure and for developing metabolomics strategies for radiation biodosimetry in humans, but need more data to consummate.
机译：放射线照射后，大规模人员的快速放射损伤早期分类对于有限的医疗资源分配和核事故后大量伤者的早期治疗至关重要。由于高通量分析和收集样品的微创，辐射代谢组学最近已应用于辐射损伤研究。在此，尝试使用高效液相色谱-电喷雾串联质谱（HPLC-ESI-MS / MS）技术尝试通过血浆氨基酸靶标分析评估急性放射损伤早期分类的可行性。非线性核偏最小二乘（KPLS）模型用于分类辐射损伤等级。暴露后5小时无辐射暴露的分类准确度为92.3％。暴露后24小时，不同剂量照射组的分类准确率均高于83％，中度和重度放射损伤的正确分类率分别为91.7％和92.3％。暴露后72小时，所有放射损伤水平的分类准确度均超过90％，中度和重度组的正确分类率高达100％。该方法可用于早期预测不同水平的辐射暴露，以及用于开发用于人体辐射生物剂量测定的代谢组学策略，但需要更多数据才能完善。

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  • 来源
    《Metabolomics》 |2013年第4期|853-863|共11页
  • 作者

    Xinxing Tang; Mingchen Zheng; Yuanyuan Zhang; Saijun Fan; Chang Wang;

  • 作者单位

    Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences (RAD-X) Medical College of Soochow University">(1);

    School of Mathematical Sciences Soochow University">(2);

    Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences (RAD-X) Medical College of Soochow University">(1);

    Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences (RAD-X) Medical College of Soochow University">(1);

    Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences (RAD-X) Medical College of Soochow University">(1);

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Radiation biodosimetry; Triage; Radiation metabolomics; Amino acids; HPLC–MS;

    机译：辐射生物剂量法;分流;辐射代谢组学;氨基酸;HPLC-MS;

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