Applications of a new subspace clustering algorithm (COSA) in medical systems biology

Doris Damian; Matej Ore?i?; Elwin Verheij; Jacqueline Meulman; Jerome Friedman; Aram Adourian; Nicole Morel; Age Smilde; Jan van der Greef

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Applications of a new subspace clustering algorithm (COSA) in medical systems biology

机译：一种新的子空间聚类算法（COSA）在医学系统生物学中的应用

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A novel clustering approach named Clustering Objects on Subsets of Attributes (COSA) has been proposed (Friedman and Meulman, (2004). Clustering objects on subsets of attributes. J. R. Statist. Soc. B 66, 1–25.) for unsupervised analysis of complex data sets. We demonstrate its usefulness in medical systems biology studies. Examples of metabolomics analyses are described as well as the unsupervised clustering based on the study of disease pathology and intervention effects in rats and humans. In comparison to principal components analysis and hierarchical clustering based on Euclidean distance, COSA shows an enhanced capability to trace partial similarities in groups of objects enabling a new discovery approach in systems biology as well as offering a unique approach to reveal common denominators of complex multi-factorial diseases in animal and human studies.

机译：有人提出了一种新颖的聚类方法，即在属性子集上聚类对象（COSA）（Friedman and Meulman，（2004）。在属性子集上聚类对象。JRStatist。Soc。B 66，1-25。），用于对属性的子集进行无监督分析。复杂的数据集。我们证明了其在医学系统生物学研究中的有用性。描述了代谢组学分析的例子以及基于对大鼠和人类疾病病理学和干预作用的研究的无监督聚类。与基于欧几里得距离的主成分分析和层次聚类相比，COSA增强了追踪对象组中部分相似性的能力，从而为系统生物学提供了一种新的发现方法，并提供了一种揭示复杂多目标共同点的独特方法。动物和人类研究中的阶乘疾病。

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来源
《Metabolomics》 |2007年第1期|69-77|共9页
作者
Doris Damian; Matej Ore?i?; Elwin Verheij; Jacqueline Meulman; Jerome Friedman; Aram Adourian; Nicole Morel; Age Smilde; Jan van der Greef;
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BG Medicine Inc. 610 Lincoln Street North Waltham MA 02451 USA;

VTT Technical Research Centre of Finland Tietotie 2 PO Box 1500 Espoo 02044 VTT Finland;

TNO Quality of life PO Box 360 Zeist 3700 AJ The Netherlands;

Data Theory Group Faculty of Social and Behavioral Sciences Leiden University PO Box 9555 Leiden 2300 RB The Netherlands;

Department of Statistics and Stanford Linear Accelerator Center Stanford University Stanford CA 94305 USA;

BG Medicine Inc. 610 Lincoln Street North Waltham MA 02451 USA;

BG Medicine Inc. 610 Lincoln Street North Waltham MA 02451 USA;

TNO Quality of life PO Box 360 Zeist 3700 AJ The Netherlands;

BG Medicine Inc. 610 Lincoln Street North Waltham MA 02451 USA;

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正文语种 eng
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COSA; subspace clustering; metabolomics; lipidomics; biomarkers; translational research; metabolic syndrome; Zucker rats; ZDF rats;

机译：COSA;亚空间聚类;代谢组学;脂质组学;生物标志物;翻译研究;代谢综合征;Zucker大鼠;ZDF大鼠;

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Applications of a new subspace clustering algorithm (COSA) in medical systems biology

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