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首页> 外文期刊>Micro & nano letters >Toxicity, morphological and structural properties of chitosan-coated Bi2O3–Bi(OH)3 nanoparticles prepared via DC arc discharge in liquid: a potential nanoparticle-based CT contrast agent
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Toxicity, morphological and structural properties of chitosan-coated Bi2O3–Bi(OH)3 nanoparticles prepared via DC arc discharge in liquid: a potential nanoparticle-based CT contrast agent

机译：壳聚糖涂层Bi 2 O 3 / sup> -bi（OH） 3 / sum>纳米颗粒的毒性，形态学和结构性能，通过DC电弧放电在液体中制备：基于临床基于纳米粒子的CT造影剂

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摘要

In this study, Bi2O3 nanoparticles were employed as computed tomography (CT) contrast agents. In this regard, X-ray attenuation of Bi2O3 nanoparticles, prepared via DC arc discharge in water, was investigated. In addition, the optical, structural, morphology and cytotoxicity properties of afforded nanoparticles were also studied. The electric arc discharge was done via bismuth electrodes in a water medium. Then, to stabilise Bi2O3 nanoparticles, chitosan molecule was cross linked via glutaraldehyde around Bi2O3 nanoparticles. X-ray diffraction analysis demonstrated the monoclinic structure and field emission-scanning electron microscopy images clarified the average size of Bi2O3 as 40 nm. Fourier transform infrared analysis proved chitosan band formation around Bi2O3 nanoparticles. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed no considerable toxicity after 72 h. Finally, X-ray CT of chitosan-coated Bi2O3 nanoparticles and Iohexol was carried out at concentrations of 1-6 mg/ml. The CT number of chitosan-coated Bi2O3 nanoparticles measured 16, 30, 49, 66, 75 and 85, as well as, respective numbers for Iohexol were 5, 14, 25, 34, 44 and 57. Therefore, it displayed that X-ray attenuation of chitosan-coated Bi2O3 nanoparticle was more in comparison with Iohexol at the same concentrations. Eventually, the results demonstrated that chitosan-coated Bi2O3 nanoparticles are a suitable candidate for commercial iodine contrast agent substitution.
机译：在该研究中，将Bi2O3纳米颗粒作为计算机断层扫描（CT）造影剂。在这方面，研究了通过DC电弧放电在水中制备的Bi2O3纳米颗粒的X射线衰减。此外，还研究了所提供的纳米颗粒的光学，结构，形态和细胞毒性特性。电弧放电通过水介质中的铋电极进行。然后，为了稳定Bi2O3纳米颗粒，壳聚糖分子通过戊二醛周围连接到Bi2O3纳米颗粒周围。 X射线衍射分析证明了单斜晶体结构和场发射扫描电子显微镜图像澄清了Bi2O3至40nm的平均尺寸。傅里叶变换红外分析证明了Bi2O3纳米粒子周围的壳聚糖带形成。 3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑鎓溴（MTT）测定显示72小时后没有显着的毒性。最后，在1-6mg / ml的浓度下进行壳聚糖涂覆的Bi2O3纳米颗粒和碘己酮的X射线CT。测定的壳聚糖涂覆的Bi2O3纳米粒子的CT数，以及碘己醇的各个数为5,14,25,34,44和57.因此，它显示了X-与相同浓度的碘己烯相比，壳聚糖涂覆的Bi2O3纳米粒子的射线衰减更加比较。最终，结果表明壳聚糖涂覆的Bi2O3纳米颗粒是商业碘造影剂取代的合适候选物。

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