Tapered metal microneedles fabricated by the hybrid process of mechanical dicing and electrochemical corrosion for drug delivery

Yan X.-X.; Liu J.-Q.; Jiang S.-D.; Yang B.; Yang C.-S.

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Tapered metal microneedles fabricated by the hybrid process of mechanical dicing and electrochemical corrosion for drug delivery

机译：通过机械切割和电化学腐蚀混合工艺制备的锥形金属微针，用于药物输送

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Metal microneedles are fabricated by the process of cutting and electrochemical corrosion. The fabricated microneedles are 400 ;C;m in length, 700 ;C;m in space and have sharp tapered tips. In a force test, these microneedles could penetrate an artificial skin and a rat??s skin well and safely. In a vitro transdermal drug delivery test, the amount of the permeated flux of calcein and of the bovine serum albumin through the treated rat skin increased by 35 and six times than that on the intact skin, respectively.

机译：金属微针是通过切削和电化学腐蚀的过程制成的。制成的微针的长度为400; C; m，空间为700; C; m，并具有尖锐的锥形尖端。在力测试中，这些微针可以安全地很好地穿透人造皮肤和大鼠的皮肤。在体外透皮药物递送测试中，钙黄绿素和牛血清白蛋白透过处理过的大鼠皮肤的渗透通量分别比完整皮肤上增加了35倍和6倍。

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《Micro & Nano Letters, IET》 |2012年第12期|p.1313-1315|共3页
作者
Yan X.-X.; Liu J.-Q.; Jiang S.-D.; Yang B.; Yang C.-S.;
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National Key Laboratory of Science and Technology on Nano/Micro Fabrication, Institute of Micro and Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China;

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2. Tapered Conical Polymer Microneedles Fabricated Using an Integrated Lens Technique for Transdermal Drug Delivery [J] . Jung-Hwan Park, Yong-Kyu Yoon, Seong-O Choi, IEEE Transactions on Biomedical Engineering . 2007,第5期

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Tapered metal microneedles fabricated by the hybrid process of mechanical dicing and electrochemical corrosion for drug delivery

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